Reaction: 1,7-dimethylxanthine to 1 product

Reaction
1,7-dimethylxanthine
DBMET00223
1-Methylxanthine
DBMET00271
Reaction type
7-N-demethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Begas E, Kouvaras E, Tsakalof A, Papakosta S, Asprodini EK: In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomed Chromatogr. 2007 Feb;21(2):190-200. [Article]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Xanthine dehydrogenase/oxidaseNot AvailableNot Availableimplied