Reaction: Testosterone to 1 product

Reaction
Testosterone
DB00624
Androstenedione
DB01536
Reaction type
N-oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Brown CM, Reisfeld B, Mayeno AN: Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742 . [Article]
  2. Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR: Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. Drug Metab Dispos. 2005 Jun;33(6):714-8. doi: 10.1124/dmd.104.003327. Epub 2005 Mar 11. [Article]
  3. Price VH: Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. Arch Dermatol. 1975 Nov;111(11):1496-1502. doi: 10.1001/archderm.111.11.1496. [Article]
  4. Weisser H, Krieg M: Kinetic analysis of androstenedione 5 alpha-reductase in epithelium and stroma of human prostate. Steroids. 1997 Aug-Sep;62(8-9):589-94. doi: 10.1016/s0039-128x(97)00042-1. [Article]
  5. Ishikawa T, Glidewell-Kenney C, Jameson JL: Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5 alpha-reductase inhibitor. J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):133-8. doi: 10.1016/j.jsbmb.2005.09.004. Epub 2005 Dec 28. [Article]
  6. Ishimaru T, Edmiston A, Pages L, Horton R: Direct conversion of testosterone to dihydrotestosterone glucuronide in man. J Clin Endocrinol Metab. 1978 Dec;47(6):1282-6. doi: 10.1210/jcem-47-6-1282. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C19Not AvailableNot Availableconfirmed
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed