Reaction: Acetaminophen to 1 product

Reaction
Acetaminophen
DB00316
NAPQI
DBMET00243
Reaction type
oxidation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE: PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150. [Article]
  2. FDA label [File]
  3. Acetaminophen data sheet, ebi.ac.uk [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2E1Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 1A2Not AvailableNot Availableimplied
Cytochrome P450 2D6Not AvailableNot Availableimplied
Cytochrome P450 2A6Not AvailableNot Availableimplied