Reaction: Epinephrine to 1 product

Reaction
Epinephrine
DB00668
Metanephrine
DBMET02192
Reaction type
methylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Eisenhofer G, Finberg JP: Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51. [Article]
  2. LABROSSE EH, AXELROD J, KETY SS: O-Methylation, the principal route of metabolism of epinephrine in man. Science. 1958 Sep 12;128(3324):593-4. [Article]
  3. Muller-Enoch D, Thomas H, Streng W, Wildfeuer W, Haferkamp O: [O-Methylation of epinephrine, 3,4-dihydroxybenzoic acid and 6,7-dihydroxycoumarin in yeasts (author's transl)]. Z Naturforsch C. 1976 Sep-Oct;31(9-10):509-13. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Catechol O-methyltransferaseNot AvailableNot Availableimplied