Reaction: Progesterone to 1 product

Reaction
Progesterone
DB00396
6β-Hydroxyprogesterone
DBMET00286
Reaction type
hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Patil AS, Swamy GK, Murtha AP, Heine RP, Zheng X, Grotegut CA: Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model. Reprod Sci. 2015 Dec;22(12):1577-86. doi: 10.1177/1933719115589414. Epub 2015 Jun 2. [Article]
  2. Nakanishi K, Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H: Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. Xenobiotica. 2018 Aug;48(8):757-763. doi: 10.1080/00498254.2017.1363444. Epub 2017 Aug 17. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed