Reaction: Nitroglycerin to 3 products
- Reaction
- Reaction type
- reduction
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Chen Z, Stamler JS: Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med. 2006 Nov;16(8):259-65. doi: 10.1016/j.tcm.2006.05.001. [Article]
- Ignarro LJ: After 130 years, the molecular mechanism of action of nitroglycerin is revealed. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7816-7. doi: 10.1073/pnas.132271799. [Article]
- Nitrostat® (Nitroglycerin) FDA Label [Link]
- FDA Approved Drug Products: Nitroglycerin in 5% Dextrose Injection, for intravenous use [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Aldehyde dehydrogenase, mitochondrial Not Available Not Available confirmed
