Reaction: Acetaminophen to 1 product

Reaction
Acetaminophen
DB00316
Acetaminophen glucuronide
DBMET00580
Reaction type
glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
  2. Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE: PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150. [Article]
  3. Acetaminophen data sheet, ebi.ac.uk [File]
Comments
52 to 57% of acetaminophen undergoes this process[A35815].
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-9Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-6Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 2B15Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-10Not AvailableNot Availableimplied