Reaction: Pentoxifylline to 1 product

Reaction
Pentoxifylline
DB00806
    Lisofylline
    DB12406
    Reaction type
    reduction
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. Lillibridge JA, Kalhorn TF, Slattery JT: Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol. Drug Metab Dispos. 1996 Nov;24(11):1174-9. [Article]
    2. Nicklasson M, Bjorkman S, Roth B, Jonsson M, Hoglund P: Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans. Chirality. 2002 Aug;14(8):643-52. doi: 10.1002/chir.10121. [Article]
    3. Peterson TC, Peterson MR, Wornell PA, Blanchard MG, Gonzalez FJ: Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction. Biochem Pharmacol. 2004 Jul 15;68(2):395-402. doi: 10.1016/j.bcp.2004.03.035. [Article]
    Comments
    Reduction of the ketone produces both (R)- and (S)-enantiomeric forms of metabolite M1.
    Enzymes
    Not Available