Reaction: Abrocitinib to 1 product

Reaction
Abrocitinib
DB14973
Abrocitinib M2 metabolite
DBMET03429
Reaction type
oxidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Tripathy S, Wentzel D, Wan XK, Kavetska O: Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma. Bioanalysis. 2021 Oct;13(19):1477-1486. doi: 10.4155/bio-2021-0128. Epub 2021 Oct 4. [Article]
  2. FDA Approved Drug Products: CIBINQO (abrocitinib) tablets, for oral use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C19Not AvailableNot Availableimplied
Cytochrome P450 2C9Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 2B6Not AvailableNot Availableimplied