New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.

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Fonvielle M, Therisod H, Hemery M, Therisod M

New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):410-3. Epub 2006 Oct 17.

PubMed ID
17088060 [ View in PubMed
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Abstract

We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 microM, might be of interest as an anti-obesity drug.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
NADHGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicProteinHumans
Unknown
Not AvailableDetails
Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Phosphoglycolohydroxamic AcidTriosephosphate isomeraseKi (nM)3000N/AN/ADetails