Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.

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Liu Y, Qiao DR, Zheng HB, Dai XL, Bai LH, Zeng J, Cao Y

Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.

Mol Biol Rep. 2008 Sep;35(3):397-403. Epub 2007 May 26.

PubMed ID

17530440 [ View in PubMed

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Abstract

NADH:ubiquinone oxidoreductase (complex I ) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone coupled to proton translocation across the membrane. The cDNA sequence of Dunaliella salina mitochondrial NADH: ubiquinone oxidoreductase 19-kD subunit contains a 682-bp ORF encoding a protein with an apparent molecular mass of 19 kD. The sequence has been submitted to the GenBank database under Accession No. EF566890 (cDNA sequences) and EF566891 (genomic sequence). The deduced amino-acid sequence is 74% identical to Chlamydomonas reinhardtii mitochondrial NADH:ubiquinone oxidoreductase 18-kD subunit. The 19-kD subunit mRNA expression was observed in oxygen deficiency, salt treatment, and rotenone treatment with lower levels. It demonstrate that the 19-kD subunit of Complex I from Dunaliella salina is regulated by these stresses.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
NADH	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	Protein	Humans	Unknown	Not Available	Details