Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.

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Bao HG, Zhao CJ, Li JY, Wu Ch

Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.

Anim Genet. 2007 Oct;38(5):514-6. Epub 2007 Jul 5.

PubMed ID
17614984 [ View in PubMed
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Abstract

NADH dehydrogenase (complex I) couples the oxidation of NADH for the reduction of ubiquinone with the generation of a proton gradient that can be used for the synthesis of ATP. We have found a missense mutation in the MT-ND5 subunit of NADH dehydrogenase in the Tibet chicken breed. In the present study, the mitochondrial respiratory control ratio (RCR) and NADH dehydrogenase activity in Tibet chicken embryonic brain with different genotypes were measured. Significant differences between animals carrying mitochondria with the EF493865.1:m.1627A vs. EF493865.1:m.1627C alleles were observed for RCR and enzyme activity.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
NADHNADH dehydrogenase [ubiquinone] 1 subunit C2ProteinHumans
Unknown
Not AvailableDetails
NADHNADH-ubiquinone oxidoreductase chain 5ProteinHumans
Unknown
Not AvailableDetails