mGluR1 in the fundic glands of rat stomach.

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San Gabriel AM, Maekawa T, Uneyama H, Yoshie S, Torii K

mGluR1 in the fundic glands of rat stomach.

FEBS Lett. 2007 Mar 20;581(6):1119-23. Epub 2007 Feb 22.

PubMed ID
17331504 [ View in PubMed
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Abstract

l-glutamate not only confers cognitive discrimination for umami taste in the oral cavity, but also conveys sensory information to vagal afferent fibers in the gastric mucosa. We used RT-PCR, western blotting, and immunohistochemistry to demonstrate that mGluR1 is located in glandular stomach. Double staining revealed that mGluR1 is found at the apical membrane of chief cells and possibly in parietal cells. Moreover, a diet with 1% l-glutamate induced changes in the expression of pepsinogen C mRNA in stomach mucosa. These data suggest that mGluR1 is involved in the gastric phase regulation of protein digestion.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Glutamic acidMetabotropic glutamate receptor 1ProteinHumans
Unknown
Not AvailableDetails