Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders.

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Yamagishi S, Matsui T, Ueda S, Fukami K, Okuda S

Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders.

Curr Drug Metab. 2009 Feb;10(2):159-63.

PubMed ID

19275550 [ View in PubMed

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Abstract

Diabetes is associated with an increase risk for cardiovascular disease (CVD). Recently, macrovascular complications of diabetes have been shown to start before the development of diabetes. Indeed, several clinical studies have confirmed the increased risk of CVD in patients with impaired glucose tolerance (IGT). Since postprandial hyperglycemia and insulin resistance are thought to play a central role in the development and progression of CVD in patients with IGT, amelioration of postprandial hyperglycemia as well as insulin resistance is a therapeutic target for the prevention of CVD in these high-risk patients. Acarbose, an alpha-glucosidase inhibitor, delays the absorption of carbohydrate from the small intestine, thereby reducing postprandial hyperglycemia. Further, recently, acarbose has been shown to improve insulin resistance in vivo. These findings suggest that acarbose is a promising metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome. In this paper, we review the clinical utility of acarbose in various cardiometabolic disorders.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Acarbose	Maltase-glucoamylase, intestinal	Protein	Humans	Yes	Inhibitor	Details