Modulation of thyroidal radioiodine uptake by theophylline.

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Lee JM, Zemans RL, Hejazi M, Chin BB, Ladenson PW, Caturegli P

Modulation of thyroidal radioiodine uptake by theophylline.

Exp Mol Pathol. 2004 Oct;77(2):116-20.

PubMed ID

15351234 [ View in PubMed

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Abstract

Diagnostic and therapeutic use of radioiodine in the management of thyroid disorders depends on the ability of thyroid cells to concentrate radioiodine, a process regulated by thyrotropin and dependent on the intracellular increase in cAMP. We tested the ability of theophylline, a drug known to increase intracellular cAMP via inhibition of phosphodiesterase, to modulate the thyroidal radioiodine uptake in FRTL-5 cells, in mice and in humans. In FRTL-5 cells, theophylline increased the uptake of radioactive iodine and intracellular cAMP only at low concentrations (1 microM). In mice, theophylline increased slightly the radioiodine uptake, although this increase varied from 1.5- to 6.6-fold. In humans, theophylline decreased slightly the radioiodine uptake, a decrease that became more pronounced with time after radioiodine administration. These studies suggest that theophylline modulates the radioiodine uptake in a dose-dependent fashion, although the modulation is mild and probably not applicable to the clinical setting.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Oxtriphylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Protein	Humans	Yes	Inhibitor	Details
Theophylline	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Protein	Humans	Yes	Inhibitor	Details