Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.

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Bendlova B, Zavadilova J, Vankova M, Vejrazkova D, Lukasova P, Vcelak J, Hill M, Cibula D, Vondra K, Starka L, Vrbikova J

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.

J Steroid Biochem Mol Biol. 2007 Apr;104(1-2):68-74. Epub 2007 Jan 26.

PubMed ID
17258903 [ View in PubMed
]
Abstract

SHBG (sex hormone-binding globulin) is a transport protein specific for dihydrotestosterone, testosterone and estradiol. The missense mutation in exon 8 (GAC-->AAC) causing the amino acid exchange Asp-->Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels. We studied possible association of this polymorphism with polycystic ovary syndrome (PCOS) and anthropometric and biochemical parameters in 248 PCOS patients and 109 healthy control women. The D327N polymorphism (wild-type and variant allele) was detected using PCR-RFLP method (restriction enzyme Bbs-I). For statistical evaluation chi(2) test, Mann-Whitney test, ANCOVA, ANOVA (NCSS 2004, Statgraphics Plus v.5.1, USA) were used. There was no significant difference in genotype distribution between PCOS and controls (chi(2)=1.03, p=0.59). Moreover, we did not find an association of the variant allele with plasma SHBG level, steroid hormones, or screened parameters of lipid and glucose metabolism. In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
EstradiolSex hormone-binding globulinProteinHumans
Unknown
Binder
Details
Estradiol acetateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Estradiol benzoateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Estradiol cypionateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Estradiol dienanthateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Estradiol valerateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Estrone sulfateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails