Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice.

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Balasubramaniyan V, Nalini N

Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice.

Singapore Med J. 2006 Oct;47(10):864-8.

PubMed ID
16990961 [ View in PubMed
]
Abstract

INTRODUCTION: This study aimed to assess the leptin dependent changes on adenosine triphosphatase (ATPase) activities of the central nervous system during chronic ethanol supplementation. METHODS: The mice were divided into four groups. Group 1 consisted of control animals that received isocaloric glucose, Group 2 animals received isocaloric glucose plus exogenous mouse recombinant leptin (230 microgrammes/kilogramme body weight intraperitoneally) every alternate day, Group 3 were alcohol-fed mice (6.32 grammes/kilogramme body weight orally), and Group 4 were alcohol-fed mice that received leptin (230 microgrammes/kilogramme body weight intraperitoneally) every alternate day. The experiment was terminated after giving the mice leptin injections for 15 days. RESULTS: Ethanol feeding for a total period of 45 days (p-value is less than 0.05) significantly elevated the brain lipid hydroperoxide levels and total ATPases, sodium, potassium-ATPase and magnesium-ATPase activities but significantly decreased the calcium-ATPase activity. Leptin injections to ethanol-fed animals further elevated the levels of lipid hydroperoxides, total ATPases, sodium, potassium-ATPase and magnesium-ATPase, while calcium-ATPase activity was reduced significantly. CONCLUSION: Leptin plays an important role in the pathogenesis of ethanol-induced neurotoxicity by enhancing brain lipid peroxidation and regulating brain ATPase activities in mice. Thus, hyperleptinaemia-induced oxidative stress and enhanced ATPase activities may be important pathogenic factors in brain toxicity.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Magnesium acetateSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
Magnesium cationSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
Magnesium lactateSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
Magnesium levulinateSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails