Recent advances in the discovery of alpha1-adrenoceptor agonists.
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Bishop MJ
Recent advances in the discovery of alpha1-adrenoceptor agonists.
Curr Top Med Chem. 2007;7(2):135-45.
- PubMed ID
- 17266602 [ View in PubMed]
- Abstract
The alpha(1) adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the alpha(1) adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known alpha(1) adrenoceptor agonists are alpha(1A) selective, but the discovery of highly selective alpha(1B) and alpha(1D) adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific alpha(1) agonists as well as contributions to our understanding of agonist-receptor interactions.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Droxidopa Alpha-1A adrenergic receptor Protein Humans YesAgonistDetails Droxidopa Alpha-1B adrenergic receptor Protein Humans YesAgonistDetails Droxidopa Alpha-1D adrenergic receptor Protein Humans YesAgonistDetails Norepinephrine Alpha-1A adrenergic receptor Protein Humans YesAgonistDetails Norepinephrine Alpha-1B adrenergic receptor Protein Humans YesAgonistDetails Norepinephrine Alpha-1D adrenergic receptor Protein Humans YesAgonistDetails