Alpha2-agonists as analgesic agents.
Article Details
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Giovannoni MP, Ghelardini C, Vergelli C, Dal Piaz V
Alpha2-agonists as analgesic agents.
Med Res Rev. 2009 Mar;29(2):339-68. doi: 10.1002/med.20134.
- PubMed ID
- 18680204 [ View in PubMed]
- Abstract
It is well known that norepinephrine is involved in the control of pain by modulating pain-related responses through various pathways. alpha(2)-Adrenergic agonists have a well-established analgesic profile and, in the recent years, have found a wider application, in particular as adjunct to anesthetics and analgesics in perioperative settings. This review analyzes the alpha(2)-agonists currently in clinical use, starting from the prototype Clonidine, as well as the most promising and studied molecules. In addition, an overview of the imidazoles, imidazolines, and hydroxyethyl-thioureas derivatives published in both the open and patented literature is presented, providing chemical description and pharmacological data. Finally, the most commonly alpha(2)-agonists used in veterinary medicine are described.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Droxidopa Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails Droxidopa Alpha-2B adrenergic receptor Protein Humans YesAgonistDetails Droxidopa Alpha-2C adrenergic receptor Protein Humans YesAgonistDetails Epinephrine Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails Norepinephrine Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails