[Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine].

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Galitzky J, Carpene C, Lafontan M, Berlan M

[Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine].

C R Acad Sci III. 1993;316(5):519-23.

PubMed ID

8106131 [ View in PubMed

]

Abstract

A new subtype of beta-adrenoceptor (beta 3) has been recently characterized in human and rodent genome. This receptor can be stimulated with catecholamines or selective pharmacological beta 3-adrenoceptor agonists and it fulfils similar function of norepinephrine in rodent and dog adipose tissue. Octopamine but not tyramine or phenylethylamine activated lipolysis in dog fat cells as well as BRL 37344 (a beta 3-adrenoceptor agonist) or norepinephrine. In human fat cells, norepinephrine was lipolytic whereas BRL 37344 or octopamine were without effect. The lipolytic effect of octopamine did not depend on beta 1-/beta 2-adrenoceptor stimulation since it was not suppressed by beta 1- or beta 2-antagonists. These results suggest that octopamine is a specific endogenous ligand for beta 3-adrenoceptors in mammals.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Norepinephrine	Beta-3 adrenergic receptor	Protein	Humans	Yes	Agonist	Details