The prevalence of hepatitis B surface antigen in commercially prepared plasma products.

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Hoofnagle JH, Gerety RJ, Thiel J, Barker LF

The prevalence of hepatitis B surface antigen in commercially prepared plasma products.

J Lab Clin Med. 1976 Jul;88(1):102-13.

PubMed ID

932529 [ View in PubMed

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Abstract

Commercially available lots of plasma derivatives prepared between 1957 and 1975 were tested for hepatitis B surface antigen (HBsAg) by radioimmunoassay. In all, 69 per cent of lots of plasma protein fraction, 40 per cent of factor IX concentrate, 20 per cent of normal serum albumin, 13 per cent of antihemophilic factor, 3 per cent of fibrinogen, and 0.7 per cent of immune serum globulin lots tested were HBsAg-positive. There was great variation in the prevalence of HBsAg-positive lots of each product among the different manufacturers, reflecting not only differences in methods of processing plasma, but also differences in donor populations. Those manufacturers relying upon volunteer donor plasma or placental source material demonstrated lower rates of HBsAg-positive lots of final products than those relying upon commercial donor plasma. There was a marked decrease in the prevalence of positive lots during the period 1971 to 1973, coincident with the onset of routine plasma donor screening for HBsAg. However, current requirements for plasma screening have not resulted in totally HBsAg-free plasma products. Use of more sensitive and more reliable tests for HBsAg will probably reduce contamination of plasma pools with HBsAg to undetectable levels. Despite HBsAg-status, however, the "high-risk" plasma products (fibrinogen, antihemophilic factor, factor IX concentrate) must still be considered capable of transmitting hepatitis and used only with the strictest indications.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Antihemophilic factor, human recombinant	Coagulation factor IX	Protein	Humans	Yes	Cofactor	Details
Lonoctocog alfa	Coagulation factor IX	Protein	Humans	Yes	Cofactor	Details
Moroctocog alfa	Coagulation factor IX	Protein	Humans	Yes	Cofactor	Details