Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.
Article Details
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Franchini M, Montagnana M
Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.
Clin Chem Lab Med. 2011 Jun;49(6):967-70. doi: 10.1515/CCLM.2011.154. Epub 2011 Mar 11.
- PubMed ID
- 21391865 [ View in PubMed]
- Abstract
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Antihemophilic factor, human recombinant Prolow-density lipoprotein receptor-related protein 1 Protein Humans UnknownModulatorDetails Lonoctocog alfa Prolow-density lipoprotein receptor-related protein 1 Protein Humans UnknownModulatorDetails Moroctocog alfa Prolow-density lipoprotein receptor-related protein 1 Protein Humans UnknownModulatorDetails