von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation.
Article Details
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Altieri DC, Capitanio AM, Mannucci PM
von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation.
Br J Haematol. 1986 Aug;63(4):703-11.
- PubMed ID
- 2942172 [ View in PubMed]
- Abstract
Severe thrombocytopenia has been reported to occur in some patients treated with a polyelectrolyte-fractionated porcine factor VIII concentrate (Hyate:C) (Kernoff et al, 1984; Gatti & Mannucci, 1984). We report here that Hyate:C induces aggregation of platelet-rich plasma in vitro accompanied by ATP release and thromboxane B2 formation, and is inhibited by EDTA and prostaglandin E1. Hyate:C induced platelet aggregation is affected by monoclonal antibodies anti-glycoprotein Ib or anti-glycoprotein IIb/IIIa and suppressed by polyclonal anti-porcine von Willebrand factor antiserum. We conclude that the aggregating ability of Hyate:C is due to porcine von Willebrand factor present in the concentrate. The occasional thrombocytopenia described after Hyate:C infusions probably results from the interaction between platelets and the porcine von Willebrand factor contaminating the concentrate.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Antihemophilic factor, human recombinant von Willebrand factor Protein Humans YesBinderDetails Lonoctocog alfa von Willebrand factor Protein Humans YesBinderDetails Moroctocog alfa von Willebrand factor Protein Humans YesBinderDetails