Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study.

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Citation

Hashimoto A, Yoshikawa M

Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study.

Eur J Pharmacol. 2005 Nov 21;525(1-3):91-3. Epub 2005 Nov 14.

PubMed ID
16289454 [ View in PubMed
]
Abstract

To elucidate the effect of an inhibitor of pyridoxal phosphate-dependent enzymes, aminooxyacetic acid, on the activity of serine racemase in vivo, we have investigated the effect of aminooxyacetic acid on the extracellular concentration of D-serine in the rat striatum using an in vivo microdialysis technique. The intrastriatal perfusion of aminooxyacetic acid caused a significant decline in the extracellular concentration of D-serine. These data, together with the fact that serine racemase is a pyridoxal phosphate-dependent enzyme, suggest that the aminooxyacetic acid-induced reduction of the extracellular D-serine may be at least in part due to the drug's ability to inhibit serine racemase.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Pyridoxal phosphateSerine racemaseProteinHumans
Unknown
Cofactor
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