Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study.
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Hashimoto A, Yoshikawa M
Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study.
Eur J Pharmacol. 2005 Nov 21;525(1-3):91-3. Epub 2005 Nov 14.
- PubMed ID
- 16289454 [ View in PubMed]
- Abstract
To elucidate the effect of an inhibitor of pyridoxal phosphate-dependent enzymes, aminooxyacetic acid, on the activity of serine racemase in vivo, we have investigated the effect of aminooxyacetic acid on the extracellular concentration of D-serine in the rat striatum using an in vivo microdialysis technique. The intrastriatal perfusion of aminooxyacetic acid caused a significant decline in the extracellular concentration of D-serine. These data, together with the fact that serine racemase is a pyridoxal phosphate-dependent enzyme, suggest that the aminooxyacetic acid-induced reduction of the extracellular D-serine may be at least in part due to the drug's ability to inhibit serine racemase.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Pyridoxal phosphate Serine racemase Protein Humans UnknownCofactorDetails