The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.

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Holmes ZR, Regan L, Chilcott I, Cohen H

The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.

Br J Haematol. 1999 Apr;105(1):98-101.

PubMed ID

10233370 [ View in PubMed

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Abstract

We have investigated the potency of the C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene as a genetic risk factor in women with a history of early (12 weeks gestation) recurrent miscarriage (three or more consecutive pregnancy losses). Fifty-seven of the total 173 (32. 9%) patients were heterozygous for the MTHFR mutation, 14/173 (8.1%) were homozygous (allele frequency 0.25). The prevalence of the MTHFR mutation in these women did not differ significantly from that in the control group of parous women with uneventful pregnancies, where 30/67 (44.8%) were heterozygous and 6/67 (9.0%) homozygous for the mutation (allele frequency 0.31; odds ratio for homozygous T/T 0.90, 95% CI 0.30-2.4). There was no association between the trimester of pregnancy loss and MTHFR genotype. We conclude that the C677T MTHFR mutation is not a risk predictor in women with a history of early or late recurrent miscarriage.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tetrahydrofolic acid	Methylenetetrahydrofolate reductase	Protein	Humans	Unknown	Cofactor	Details