[Role of transamination in the mobilization of respiratory substrates in germinating seeds of castor oil plants].

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Popov VN, Eprintsev AT, Fedorin DN, Fomenko OIu, Igamberdiev AU

[Role of transamination in the mobilization of respiratory substrates in germinating seeds of castor oil plants].

Prikl Biokhim Mikrobiol. 2007 May-Jun;43(3):376-81.

PubMed ID

17619587 [ View in PubMed

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Abstract

The metabolism of 1,4-14C-succinate and 2,3-14C-succinate and the activity of succinic semialdehyde dehydrogenase (EC 1.2.1.16) were studied in germinating seeds of castor oil plants (Ricinus communis L.). Succinate metabolism involved succinate dehydrogenase and was sensitive to metabolites of the gamma-aminobutyric acid shunt. Considerable accumulation of the label in amino acids reflected the progression of transamination reactions. Succinic semialdehyde dehydrogenase was purified from the endosperm of castor oil plants. Kinetic characteristics of the enzyme were evaluated. Our study indicates that the mobilization of respiratory substrates during germination of castor oil plants is related to active transamination of ketoacids in the Krebs cycle and involves the gamma-aminobutyric acid shunt.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Succinic acid	Succinate-semialdehyde dehydrogenase, mitochondrial	Protein	Humans	Unknown	Inhibitor	Details