Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats.

Article Details

Citation

Copy to clipboard

Yalcinkaya S, Unlucerci Y, Uysal M

Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats.

Exp Toxicol Pathol. 2007 Aug;58(6):455-9. Epub 2007 May 11.

PubMed ID

17498936 [ View in PubMed

]

Abstract

The purpose of this study was to investigate whether high methionine (HM) diet may influence the development of ethanol-induced hepatotoxicity and prooxidant-antioxidant balance in the liver. Rats received drinking water containing ethanol (20% v/v) and/or methionine supplemented diet (2% w/w) for 75 days. Although prooxidant-antioxidant balance did not change in the liver of rats in HM group, ethanol treatment was observed to increase plasma transaminase activities, and malondialdehyde (MDA) and protein carbonyl (PC) levels, but not glutathione (GSH), vitamin E and vitamin C levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities in the liver of rats as compared to controls. However, ethanol plus HM diet caused further increases in plasma transaminase activities and hepatic MDA and PC levels. In addition, SOD, GSH-Px and GST activities were observed to decrease, but GSH, vitamin E and vitamin C levels remained unchanged in the liver as compared to ethanol, HM and control groups. Our results show that HM diet may augment hepatotoxicity and oxidative stress in the liver of chronically ethanol-treated rats.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Glutathione	Glutathione S-transferase Mu 2	Protein	Humans	Unknown	Not Available	Details