Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane.

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Rao AV, Shaha C

Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane.

FEBS Lett. 2001 Oct 26;507(2):174-80.

PubMed ID
11684093 [ View in PubMed
]
Abstract

Phase II detoxification enzymes, the glutathione S-transferases (GSTs) of 24 kDa are known to be cytosolic enzymes. This study shows that multiple GST isoforms that are 24 kDa in size are present on the extracellular side of the plasma membrane of rat male germ cells. The GST activity of male germ cell plasma membranes is several folds higher than somatic cell plasma membrane GST activity. Isoform composition of the germ cell plasma membrane and the cytosolic pool differ, GSTM5 and GSTPi being absent on the plasma membranes. The molecular masses of the common isoforms are comparable between the two pools and both pools show GST and glutathione peroxidase activity.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
GlutathioneGlutathione S-transferase Mu 5ProteinHumans
Unknown
Not AvailableDetails