Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes.

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Bashir Q, Rashid N, Akhtar M

Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes.

Chem Commun (Camb). 2006 Dec 28;(48):5065-7. Epub 2006 Oct 13.

PubMed ID

17146529 [ View in PubMed

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Abstract

The condensation process catalysed by 2-amino-3-oxobutyrate CoA ligase (KBL; also known as 2-amino-3-ketobutyrate ligase) involves the loss of the pro-R hydrogen atom of glycine and occurs with the inversion of stereochemistry; a similar scenario is envisaged for the condensation step of other alpha-oxoamine synthases.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Glycine	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	Protein	Humans	Unknown	Substrate	Details