Inherited neuropathies: new genes don't fit old models.

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Scherer SS

Inherited neuropathies: new genes don't fit old models.

Neuron. 2006 Sep 21;51(6):672-4.

PubMed ID

16982409 [ View in PubMed

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Abstract

Mutations in GARS cause dominantly inherited neuropathies in humans. GARS encodes glycyl-tRNA synthetase, the enzyme that couples glycine to its tRNA. In this issue of Neuron, Seburn et al. have identified and characterized a mutant mouse with a dominantly inherited axonal neuropathy caused by a Gars mutation that is inferred to have a gain of function.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Glycine	Glycine--tRNA ligase	Protein	Humans	Unknown	Substrate	Details