The effect of dietary cysteine level on cysteine metabolism in rats.

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Daniels KM, Stipanuk MH

The effect of dietary cysteine level on cysteine metabolism in rats.

J Nutr. 1982 Nov;112(11):2130-41.

PubMed ID

7131091 [ View in PubMed

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Abstract

Male, Sprague-Dawley rats were fed L-amino acid diets that contained 0.4% L methionine and either 0, 0.2% (control), or 2.6% L-cysteine (free base) for 5 or 20 days. Hepatic cysteine dioxygenase activity in rats fed 2.6% cysteine was 5 and 3-times as great as in pair-fed control rats at 5 and 20 days, respectively. Cysteine sulfinate decarboxylase activity in liver of rats fed 2.6% cysteine for 20 days was about 40% of the pair-fed control level. The activity of cysteine sulfinate aminotransferase and the rate of cysteine desulfhydration were not influenced by dietary cysteine content. Rats that had been fed these diets for 5 days were intubated with 5 g of diet that contained either 0.2% or 2.6% L-[35S] cysteine. The 24-hour urinary excretion of total 35S, 35SO4, and [35S] taurine by rats that had been fed 2.6% cysteine for 5 days and intubated with 0.2% L[35S] cysteine was 1.4-, 1.8-, and 2.4-fold, respectively, that of pair-fed control rats. About 2.1, 1.8, and 9.1 times as much 35S, 35SO4, and [35S] taurine, respectively, were excreted by rats fed 2.6% cysteine for 5 days and intubated with 2.6% L-[35S] cysteine as was excreted by pair-fed control rats. Urinary excretion of these metabolites was not different between rats fed 0 and 0.2% cysteine. These results indicate that the cysteine sulfinate pathway plays a major regulatory role in the metabolism of excess cysteine.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cysteine	Cysteine sulfinic acid decarboxylase	Protein	Humans	Unknown	Not Available	Details