Adenosine kinase from rat liver: new biochemical properties.

Article Details

Citation

Copy to clipboard

Leoncini R, Vannoni D, Santoro A, Giglioni S, Carli R, Marinello E

Adenosine kinase from rat liver: new biochemical properties.

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1107-12.

PubMed ID

17065073 [ View in PubMed

]

Abstract

Adenosine kinase is a well-known enzyme which catalyzes the phosphorylation of adenosine to AMP: Its metabolic and kinetic properties are well studied. Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Cells could exploited this property in situations in which ATP levels are strongly decreased and ADP decreases slowly.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Adenosine phosphate	Adenosine kinase	Protein	Humans	Unknown	Product of	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
ATP	Adenosine kinase	Protein	Humans	Unknown	Substrate	Details