Differential gene expression of organic anion transporters in male and female rats.
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Kobayashi Y, Hirokawa N, Ohshiro N, Sekine T, Sasaki T, Tokuyama S, Endou H, Yamamoto T
Differential gene expression of organic anion transporters in male and female rats.
Biochem Biophys Res Commun. 2002 Jan 11;290(1):482-7.
- PubMed ID
- 11779196 [ View in PubMed]
- Abstract
Sex-related differential gene expression of organic anion transporters (rOAT1, rOAT2, and rOAT3) in rat brain, liver, and kidney was investigated. There were no sex differences in the expression of rOAT1 mRNA. rOAT2 mRNA was abundant in the liver and weakly expressed in the kidney of male rats; however, the OAT2 gene was strongly expressed in both organs of females. The abundance of rOAT2 mRNA markedly increased in castrated male rat kidney; however, treatment of castrated male rats with testosterone led to a decrease of rOAT2 mRNA. Expression of rOAT3 mRNA in intact female rats was found in the kidney and brain, whereas in males rOAT3 mRNA was also found in the liver. rOAT3 mRNA markedly decreased in the liver of castrated male rats but increased in testosterone-treated castrated male rats. Moreover, rOAT3 mRNA increased in the hypophysectomized female rat liver, indicating that rOAT3 is an inducible isoform. The present findings suggest that sex steroids play an important role in the expression and maintenance of OAT2/3 isoforms in the rat liver and kidney. Our results provide information on the differential gene expression of OAT isoforms with sex hormone dependency.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Methyltestosterone Solute carrier family 22 member 8 Protein Humans UnknownInducerDetails Testosterone Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Testosterone Solute carrier family 22 member 8 Protein Humans UnknownInducerDetails Testosterone cypionate Solute carrier family 22 member 7 Protein Humans UnknownInducerDetails Testosterone cypionate Solute carrier family 22 member 8 Protein Humans UnknownInducerDetails Testosterone enanthate Solute carrier family 22 member 7 Protein Humans UnknownInducerDetails Testosterone enanthate Solute carrier family 22 member 8 Protein Humans UnknownInducerDetails Testosterone undecanoate Solute carrier family 22 member 7 Protein Humans UnknownInducerDetails Testosterone undecanoate Solute carrier family 22 member 8 Protein Humans UnknownInducerDetails