Identification of a nuclear receptor for bile acids.

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Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B

Identification of a nuclear receptor for bile acids.

Science. 1999 May 21;284(5418):1362-5.

PubMed ID

10334992 [ View in PubMed

]

Abstract

Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Chenodeoxycholic acid	Bile acid receptor	Protein	Humans	Unknown	Other	Details

Polypeptides

Name	UniProt ID
Bile acid receptor	Q96RI1	Details