Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.
Article Details
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Beakley BD, Kaye AM, Kaye AD
Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.
Pain Physician. 2015 Jul-Aug;18(4):395-400.
- PubMed ID
- 26218943 [ View in PubMed]
- Abstract
BACKGROUND: Serotonin syndrome is a mild to potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being presented involving the use of tramadol. METHODS: This review article contains an overview of serotonin syndrome while specifically looking at tramadol's pharmacology and risk factors for serotonin syndrome. With tramadol's increasing popularity, the goal of this article is to make physicians more alert and aware of this potential side effect associated with tramadol. CONCLUSIONS: In conclusion, with the increasing incidence of serotonin syndrome, prescribing physicians should be aware of and educate their patients on the potential side effects of tramadol. It is important that the prescribing physician reviews patient medications for concurrent serotonergic drugs and monitors for potential abuse.
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- Drugs
- Drug Reactions
Reaction Details - Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
Drugs Interaction Integrate drug-drug
interactions in your softwareTramadolCyclobenzaprine The risk or severity of serotonin syndrome and seizure can be increased when Cyclobenzaprine is combined with Tramadol. TramadolBuprenorphine The risk or severity of serotonin syndrome can be increased when Buprenorphine is combined with Tramadol. TramadolMethotrimeprazine The risk or severity of serotonin syndrome can be increased when Methotrimeprazine is combined with Tramadol. TramadolRotigotine The risk or severity of serotonin syndrome can be increased when Rotigotine is combined with Tramadol. TramadolTapentadol The risk or severity of serotonin syndrome can be increased when Tapentadol is combined with Tramadol.
