Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine deoxygenase.

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Oien DB, Moskovitz J

Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine deoxygenase.

Biochem Biophys Res Commun. 2007 Jan 12;352(2):556-9. Epub 2006 Nov 20.

PubMed ID

17126812 [ View in PubMed

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Abstract

Methionine sulfoxide reductases (Msrs) are able to reduce methionine sulfoxide to methionine both in proteins and free amino acids. By their action it is possible to regulate the function of specific proteins and the cellular antioxidant defense against oxidative damage. Similarly, cysteine deoxygenase (CDO) may be involved in the regulation of protein function and antioxidant defense mechanisms by its ability to oxidized cysteine residues. The two enzymes' involvement in sulfur amino-acids metabolism seems to be connected. Lack of methionine sulfoxide reductase A (MsrA) in liver of MsrA-/- led to a significant drop in the cellular level of thiol groups and lowered the CDO level of expression. Moreover, following selenium deficient diet (applied to decrease the expression levels of selenoproteins like MsrB), the latter effect was maintained while the basal levels of thiol decreased in both mouse strains. We suggest that both enzymes are working in coordination to balance cellular antioxidant defense.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Methionine	Mitochondrial peptide methionine sulfoxide reductase	Protein	Humans	Unknown	Substrate	Details