The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease.

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Ward AC

The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease.

Front Biosci. 2007 Jan 1;12:608-18.

PubMed ID

17127322 [ View in PubMed

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is a key regulator of granulopoiesis via stimulation of a specific cell-surface receptor, the G-CSF-R, found on hematopoietic progenitor cells as well as neutrophilic granulocytes. It is perhaps not surprising, therefore, that mutations of the G-CSF-R has been implicated in several clinical settings that affect granulocytic differentiation, particularly severe congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia. However, other studies suggest that signalling via the G-CSF-R is also involved in a range of other malignancies. This review focuses on the molecular mechanisms through which the G-CSF-R contributes to disease.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Filgrastim	Granulocyte colony-stimulating factor receptor	Protein	Humans	Yes	Stimulator	Details
Pegfilgrastim	Granulocyte colony-stimulating factor receptor	Protein	Humans	Yes	Agonist	Details