Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

Article Details

Citation

Copy to clipboard

Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O'Brien A, White A, Kennedy JM, Craymer K, Farrington L, Auh JS

Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

NIDA Res Monogr. 1998 Mar;178:440-66.

PubMed ID

9686407 [ View in PubMed

]

Abstract

Not Available

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dopamine	5-hydroxytryptamine receptor 1A	Protein	Humans	Unknown	Binder	Details
Imipramine	D(1) dopamine receptor (Protein Group)	Protein group	Humans	Unknown	Binder	Details

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Apomorphine	5-hydroxytryptamine receptor 1A	Ki (nM)	4929	N/A	N/A	Details
Apomorphine	Dopamine D1 receptor	Ki (nM)	400	N/A	N/A	Details
Bromocriptine	5-hydroxytryptamine receptor 1A	Ki (nM)	25	N/A	N/A	Details
Bromocriptine	Dopamine D1 receptor	Ki (nM)	2070	N/A	N/A	Details
Buprenorphine	Delta-type opioid receptor	Ki (nM)	4.5	N/A	N/A	Details
Buprenorphine	Kappa-type opioid receptor	Ki (nM)	0.8	N/A	N/A	Details
Chlorpromazine	5-hydroxytryptamine receptor 1A	Ki (nM)	3115	N/A	N/A	Details
Chlorpromazine	Dopamine D1 receptor	Ki (nM)	44	N/A	N/A	Details
Desipramine	5-hydroxytryptamine receptor 1A	Ki (nM)	>10000	N/A	N/A	Details
Diprenorphine	Delta-type opioid receptor	Ki (nM)	0.5	N/A	N/A	Details
Diprenorphine	Kappa-type opioid receptor	Ki (nM)	0.2	N/A	N/A	Details
Dopamine	5-hydroxytryptamine receptor 1A	Ki (nM)	8248	N/A	N/A	Details
Dopamine	Dopamine D1 receptor	Ki (nM)	4470	N/A	N/A	Details
Fentanyl	Delta-type opioid receptor	Ki (nM)	152.7	N/A	N/A	Details
Fentanyl	Kappa-type opioid receptor	Ki (nM)	84.8	N/A	N/A	Details
Flupentixol	Dopamine D1 receptor	Ki (nM)	3	N/A	N/A	Details
Fluphenazine	Dopamine D1 receptor	Ki (nM)	7	N/A	N/A	Details
Haloperidol	Dopamine D1 receptor	Ki (nM)	58	N/A	N/A	Details
Imipramine	5-hydroxytryptamine receptor 1A	Ki (nM)	>10000	N/A	N/A	Details
Mianserin	5-hydroxytryptamine receptor 1A	Ki (nM)	2592	N/A	N/A	Details
Morphine	Delta-type opioid receptor	Ki (nM)	140	N/A	N/A	Details
Morphine	Kappa-type opioid receptor	Ki (nM)	46.9	N/A	N/A	Details
Naloxone	Delta-type opioid receptor	Ki (nM)	67.5	N/A	N/A	Details
Naloxone	Kappa-type opioid receptor	Ki (nM)	2.5	N/A	N/A	Details
Pentazocine	Kappa-type opioid receptor	Ki (nM)	2.2	N/A	N/A	Details
Propranolol	5-hydroxytryptamine receptor 1A	Ki (nM)	272	N/A	N/A	Details
Yohimbine	5-hydroxytryptamine receptor 1A	Ki (nM)	642	N/A	N/A	Details