Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.

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Ohe T, Hirobe M, Mashino T

Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.

Drug Metab Dispos. 2000 Feb;28(2):110-2.

PubMed ID

10640505 [ View in PubMed

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Abstract

We have already reported that the quinol formation from some para-alkylphenols, which is a novel metabolic pathway catalyzed by cytochrome P-450, occurs in a rat liver microsomal system (). In the present study, we investigated whether estrone and 17beta-estadiol, each of which contains a p-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450. Six recombinant human cytochrome P-450 enzymes, CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, and CYP3A4, were tested. The results show that estrone and 17beta-estadiol were converted into the corresponding quinols by CYP1A1, CYP2B6, and CYP2E1.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Estrone	Cytochrome P450 1A1	Protein	Humans	Unknown	Substrate	Details
Estrone	Cytochrome P450 2E1	Protein	Humans	Unknown	Substrate	Details