New insights into corticosteroid-binding globulin and glucocorticoid delivery.
Article Details
- CitationCopy to clipboard
Henley DE, Lightman SL
New insights into corticosteroid-binding globulin and glucocorticoid delivery.
Neuroscience. 2011 Apr 28;180:1-8. doi: 10.1016/j.neuroscience.2011.02.053. Epub 2011 Mar 1.
- PubMed ID
- 21371536 [ View in PubMed]
- Abstract
Corticosteroid-binding globulin (CBG) binds cortisol with high affinity and facilitates its transport in the blood. A recent discovery suggests that CBG may have a role beyond that of a simple transport carrier protein. CBG functions as a protein thermocouple that is exquisitely sensitive to temperature change, releasing cortisol in response to increasing temperatures within the human physiological range. It is also expressed in the human hypothalamus and cerebrospinal fluid, while in the rodent it is also found in other intracellular neuronal locations, suggesting a role in regulating access of glucocorticoids to their receptors in the CNS. Genetic variants of CBG have been detected in man and have been associated with fatigue-pain syndromes and hypotension, again suggesting a potential effect of CBG on the access of cortisol to brain glucocorticoid receptors. These new findings provide the basis for a novel concept of the mechanisms through which the body regulates access of glucocorticoids to the brain and other tissues of the body.
DrugBank Data that Cites this Article
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Hydrocortisone Corticosteroid-binding globulin Protein Humans UnknownBinderDetails Hydrocortisone aceponate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone acetate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone butyrate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone cypionate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone phosphate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone probutate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details Hydrocortisone valerate Corticosteroid-binding globulin Protein Humans UnknownNot Available Details