Insulin receptor signaling in the development of neuronal structure and function.

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Chiu SL, Cline HT

Insulin receptor signaling in the development of neuronal structure and function.

Neural Dev. 2010 Mar 15;5:7. doi: 10.1186/1749-8104-5-7.

PubMed ID

20230616 [ View in PubMed

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Abstract

Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit signals within the neuronal network so that animals can adapt to the constant changing environment. Insulin receptor signaling, which has been extensively studied in peripheral organ systems such as liver, muscle and adipocyte, has recently been shown to play important roles in the central nervous system. Here we review the current understanding of the underlying mechanisms that regulate structural and functional aspects of circuit development, particularly with respect to the role of insulin receptor signaling in synaptic function and the development of dendritic arbor morphology. The potential link between insulin receptor signaling malfunction and neurological disorders will also be discussed.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Insulin human	Insulin receptor	Protein	Humans	Yes	Agonist	Details