Biology of PXR: role in drug-hormone interactions.

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Wang J, Dai S, Guo Y, Xie W, Zhai Y

Biology of PXR: role in drug-hormone interactions.

EXCLI J. 2014 Jul 7;13:728-39. eCollection 2014.

PubMed ID

26417296 [ View in PubMed

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Abstract

Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug metabolizing enzymes (DMEs) and transporters. Pregnane X receptor (PXR, NR1I2) functions as a master xenobiotic receptor involved in drug metabolism and drug-drug interactions by its coordinated transcriptional regulation of phase I and phase II DMEs and transporters. Recently, increasing evidences indicate that PXR can also mediate the endocrine disruptor function and thus impact the integrity of the endocrine system. This review focuses primarily on the recent advances in our understanding of the function of PXR in glucocorticoid, mineralocorticoid, androgen and estrogen homeostasis. The elucidation of PXR-mediated drug-hormone interactions might have important therapeutic implications in dealing with hormone-dependent diseases and safety assessment of drugs.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Estradiol	Nuclear receptor subfamily 1 group I member 2	Protein	Humans	Unknown	Binder	Details