The pharmacokinetics of intravenous estradiol--a preliminary study.

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White CM, Ferraro-Borgida MJ, Fossati AT, McGill CC, Ahlberg AW, Feng YJ, Heller GV, Chow MS

The pharmacokinetics of intravenous estradiol--a preliminary study.

Pharmacotherapy. 1998 Nov-Dec;18(6):1343-6.

PubMed ID
9855336 [ View in PubMed
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Abstract

Estradiol USP was extemporaneously compounded for intravenous administration. Eight postmenopausal women were randomized to receive one of four estradiol dosages. Serum estradiol concentrations were determined at frequent intervals after single bolus dosing. The concentration-time profile was stripped and fit, and pharmacokinetic values were generated. Approximate dosage proportionality was seen with area under the curve, the terminal half-life was 27.45+/-5.65 minutes, and volume of distribution was very low (0.082+/-0.015 L/kg). Estradiol was well tolerated by all study participants.

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