PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

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McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062.

PubMed ID

24892773 [ View in PubMed

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Abstract

Not Available

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Acetylsalicylic acid	Arylamine N-acetyltransferase 2	Protein	Humans	Unknown	Substrate	Details

Pharmaco-genomics

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*14A	Not Available	G > A | T > A | C > A (rs4986782)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*14B	Not Available	G > A (rs4986782)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*15	Not Available	C > T (rs5030839)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*17	Not Available	C > T (rs56379106)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*19A	Not Available	C > T (rs56318881)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*19B	Not Available	C > T | C > T (rs56318881)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 1 Gene symbol: NAT1 UniProt: P18440	NAT1*22	Not Available	A > T (rs56172717)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5A	Not Available	T > C | C > T (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5B	Not Available	T > C | C > T | A > G (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5C	Not Available	T > C | A > G (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5D	Not Available	T > C (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5E	Not Available	T > C | G > A (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5F	Not Available	T > C | C > T | C > T | A > G (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5G	Not Available	T > C | C > T | C > T | A > G (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5H	Not Available	T > C | C > T | A > G | S287 Frameshift (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5I	Not Available	T > C | C > T | A > T | A > G (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*5J	Not Available	T > C | C > T | G > A (rs1801280)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*6A	Not Available	G > A | C > T (rs1799930)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*6B	Not Available	G > A (rs1799930)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*6C	Not Available	G > A | C > T | A > G (rs1799930)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*6D	Not Available	G > A | C > T | T > C (rs1799930)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*6E	Not Available	G > A | C > T (rs1799930)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*7A	Not Available	G > A (rs1799931)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*7B	Not Available	G > A | C > T (rs1799931)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*10	Not Available	G > A (rs72554617)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*12D	Not Available	G > A | A > G (rs4986996)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14A	Not Available	G > A (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14B	Not Available	G > A | C > T (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14C	Not Available	G > A | T > C | C > T | A > G (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14D	Not Available	G > A | C > T | G > A (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14E	Not Available	G > A | A > G (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14F	Not Available	G > A | T > C | A > G (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*14G	Not Available	G > A | C > T | A > G (rs1801279)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*17	Not Available	A > C (rs72554616)	ADR Inferred	Associated with systemic lupus erythematosus.	Details
Hydralazine	Arylamine N-acetyltransferase 2 Gene symbol: NAT2 UniProt: P11245	NAT2*19	Not Available	C > T (rs1805158)	ADR Inferred	Associated with systemic lupus erythematosus.	Details