Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

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Buchanan JG, Wightman RH

Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

Nucleic Acids Symp Ser. 1991;(25):53-4. doi: 10.1002/chin.199031303.

PubMed ID

1842094 [ View in PubMed

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Abstract

The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Aspartic acid	Multifunctional protein ADE2	Protein	Humans	Unknown	Substrate	Details