Oxidative stress modulates theophylline effects on steroid responsiveness.

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Marwick JA, Wallis G, Meja K, Kuster B, Bouwmeester T, Chakravarty P, Fletcher D, Whittaker PA, Barnes PJ, Ito K, Adcock IM, Kirkham PA

Oxidative stress modulates theophylline effects on steroid responsiveness.

Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802. doi: 10.1016/j.bbrc.2008.10.065. Epub 2008 Oct 23.

PubMed ID

18951874 [ View in PubMed

]

Abstract

Oxidative stress is a central factor in many chronic inflammatory diseases such as severe asthma and chronic obstructive pulmonary disease (COPD). Oxidative stress reduces the anti-inflammatory corticosteroid action and may therefore contribute to the relative corticosteroid insensitivity seen in these diseases. Low concentrations of theophylline can restore the anti-inflammatory action of corticosteroids in oxidant exposed cells, however the mechanism remains unknown. Here, we demonstrate that a low concentration of theophylline restores corticosteroid repression of pro-inflammatory mediator release and histone acetylation in oxidant exposed cells. Global gene expression analysis shows that theophylline regulates distinct pathways in naive and oxidant exposed cells and reverses oxidant mediated modulated of pathways. Furthermore, quantitative chemoproteomics revealed that theophylline has few high affinity targets in naive cells but an elevated affinity in oxidant stressed cells. In conclusion, oxidative stress alters theophylline binding profile and gene expression which may result in restoration of corticosteroid function.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Theophylline	Copine-1	Protein	Humans	Unknown	Not Available	Details
Theophylline	Minor histocompatibility antigen H13	Protein	Humans	Unknown	Not Available	Details
Theophylline	Nodal modulator 1	Protein	Humans	Unknown	Not Available	Details
Theophylline	Poly [ADP-ribose] polymerase 1	Protein	Humans	Unknown	Not Available	Details
Theophylline	Protein RIC-3	Protein	Humans	Unknown	Not Available	Details
Theophylline	Tubulin monoglycylase TTLL3	Protein	Humans	Unknown	Not Available	Details

Pharmaco-transcriptomics

Drug	Drug Groups	Gene	Gene ID	Change	Interaction	Chromosome
Hydrogen peroxide	Approved Vet Approved	ABHD18	80167	downregulated	Hydrogen Peroxide results in decreased expression of ABHD18 mRNA	4q28.2
Hydrogen peroxide	Approved Vet Approved	ADAMTS10	81794	downregulated	Hydrogen Peroxide results in decreased expression of ADAMTS10 mRNA	19p13.2
Hydrogen peroxide	Approved Vet Approved	ADD3	120	upregulated	Hydrogen Peroxide results in increased expression of ADD3 mRNA	10q25.1-q25.2
Hydrogen peroxide	Approved Vet Approved	ADGRG5	221188	upregulated	Hydrogen Peroxide results in increased expression of ADGRG5 mRNA	16q21
Hydrogen peroxide	Approved Vet Approved	AK3	50808	upregulated	Hydrogen Peroxide results in increased expression of AK3 mRNA	9p24.1
Hydrogen peroxide	Approved Vet Approved	ALAD	210	upregulated	Hydrogen Peroxide results in increased expression of ALAD mRNA	9q32
Hydrogen peroxide	Approved Vet Approved	ALDH6A1	4329	upregulated	Hydrogen Peroxide results in increased expression of ALDH6A1 mRNA	14q24.3
Hydrogen peroxide	Approved Vet Approved	ANKRD40	91369	upregulated	Hydrogen Peroxide results in increased expression of ANKRD40 mRNA	17q21.33
Hydrogen peroxide	Approved Vet Approved	ANKRD44	91526	upregulated	Hydrogen Peroxide results in increased expression of ANKRD44 mRNA	2q33.1
Hydrogen peroxide	Approved Vet Approved	ANP32A	8125	upregulated	Hydrogen Peroxide results in increased expression of ANP32A mRNA	15q23
Hydrogen peroxide	Approved Vet Approved	AP4E1	23431	upregulated	Hydrogen Peroxide results in increased expression of AP4E1 mRNA	15q21.2
Hydrogen peroxide	Approved Vet Approved	APOBEC3B	9582	downregulated	Hydrogen Peroxide results in decreased expression of APOBEC3B mRNA	22q13.1
Hydrogen peroxide	Approved Vet Approved	ARHGAP18	93663	upregulated	Hydrogen Peroxide results in increased expression of ARHGAP18 mRNA	6q22.33
Hydrogen peroxide	Approved Vet Approved	ARL5A	26225	upregulated	Hydrogen Peroxide results in increased expression of ARL5A mRNA	2q23.3
Hydrogen peroxide	Approved Vet Approved	ARMC7	79637	downregulated	Hydrogen Peroxide results in decreased expression of ARMC7 mRNA	17q25.1
Hydrogen peroxide	Approved Vet Approved	ATF1	466	downregulated	Hydrogen Peroxide results in decreased expression of ATF1 mRNA	12q13.12
Hydrogen peroxide	Approved Vet Approved	ATF2	1386	downregulated	Hydrogen Peroxide results in decreased expression of ATF2 mRNA	2q31.1
Hydrogen peroxide	Approved Vet Approved	ATM	472	upregulated	Hydrogen Peroxide results in increased expression of ATM mRNA	11q22.3
Hydrogen peroxide	Approved Vet Approved	ATP11A	23250	upregulated	Hydrogen Peroxide results in increased expression of ATP11A mRNA	13q34
Hydrogen peroxide	Approved Vet Approved	ATRX	546	upregulated	Hydrogen Peroxide results in increased expression of ATRX mRNA	Xq21.1
Hydrogen peroxide	Approved Vet Approved	ATXN1	6310	upregulated	Hydrogen Peroxide results in increased expression of ATXN1 mRNA	6p22.3
Hydrogen peroxide	Approved Vet Approved	AVL9	23080	upregulated	Hydrogen Peroxide results in increased expression of AVL9 mRNA	7p14.3
Hydrogen peroxide	Approved Vet Approved	BANP	54971	downregulated	Hydrogen Peroxide results in decreased expression of BANP mRNA	16q24.2
Hydrogen peroxide	Approved Vet Approved	BRWD1	54014	upregulated	Hydrogen Peroxide results in increased expression of BRWD1 mRNA	21q22.2
Hydrogen peroxide	Approved Vet Approved	CA5BP1	340591	upregulated	Hydrogen Peroxide results in increased expression of CA5BP1 mRNA	Xp22.2
Hydrogen peroxide	Approved Vet Approved	CAAP1	79886	upregulated	Hydrogen Peroxide results in increased expression of CAAP1 mRNA	9p21.2
Hydrogen peroxide	Approved Vet Approved	CASC4	113201	upregulated	Hydrogen Peroxide results in increased expression of CASC4 mRNA	15q15.3
Hydrogen peroxide	Approved Vet Approved	CBLB	868	downregulated	Hydrogen Peroxide results in decreased expression of CBLB mRNA	3q13.11
Hydrogen peroxide	Approved Vet Approved	CBLL1	79872	downregulated	Hydrogen Peroxide results in decreased expression of CBLL1 mRNA	7q22.3
Hydrogen peroxide	Approved Vet Approved	CBR4	84869	upregulated	Hydrogen Peroxide results in increased expression of CBR4 mRNA	4q32.3
Hydrogen peroxide	Approved Vet Approved	CCDC126	90693	upregulated	Hydrogen Peroxide results in increased expression of CCDC126 mRNA	7p15.3
Hydrogen peroxide	Approved Vet Approved	CCDC14	64770	upregulated	Hydrogen Peroxide results in increased expression of CCDC14 mRNA	3q21.1
Hydrogen peroxide	Approved Vet Approved	CCDC30	728621	upregulated	Hydrogen Peroxide results in increased expression of CCDC30 mRNA	1p34.2
Hydrogen peroxide	Approved Vet Approved	CCDC38	120935	upregulated	Hydrogen Peroxide results in increased expression of CCDC38 mRNA	12q23.1
Hydrogen peroxide	Approved Vet Approved	CCDC6	8030	downregulated	Hydrogen Peroxide results in decreased expression of CCDC6 mRNA	10q21.2
Hydrogen peroxide	Approved Vet Approved	CCDC88A	55704	upregulated	Hydrogen Peroxide results in increased expression of CCDC88A mRNA	2p16.1
Hydrogen peroxide	Approved Vet Approved	CCSAP	126731	upregulated	Hydrogen Peroxide results in increased expression of CCSAP mRNA	1q42.13
Hydrogen peroxide	Approved Vet Approved	CDCP1	64866	downregulated	Hydrogen Peroxide results in decreased expression of CDCP1 mRNA	3p21.31
Hydrogen peroxide	Approved Vet Approved	CDK12	51755	upregulated	Hydrogen Peroxide results in increased expression of CDK12 mRNA	17q12
Hydrogen peroxide	Approved Vet Approved	CDKAL1	54901	downregulated	Hydrogen Peroxide results in decreased expression of CDKAL1 mRNA	6p22.3
Hydrogen peroxide	Approved Vet Approved	CDKN2AIPNL	91368	upregulated	Hydrogen Peroxide results in increased expression of CDKN2AIPNL mRNA	5q31.1
Hydrogen peroxide	Approved Vet Approved	CEP57	9702	upregulated	Hydrogen Peroxide results in increased expression of CEP57 mRNA	11q21
Hydrogen peroxide	Approved Vet Approved	CHCHD4	131474	upregulated	Hydrogen Peroxide results in increased expression of CHCHD4 mRNA	3p25.1
Hydrogen peroxide	Approved Vet Approved	CHN2	1124	downregulated	Hydrogen Peroxide results in decreased expression of CHN2 mRNA	7p14.3
Hydrogen peroxide	Approved Vet Approved	CHRM5	1133	downregulated	Hydrogen Peroxide results in decreased expression of CHRM5 mRNA	15q14
Hydrogen peroxide	Approved Vet Approved	CIPC	85457	upregulated	Hydrogen Peroxide results in increased expression of CIPC mRNA	14q24.3
Hydrogen peroxide	Approved Vet Approved	CLCN3	1182	upregulated	Hydrogen Peroxide results in increased expression of CLCN3 mRNA	4q33
Hydrogen peroxide	Approved Vet Approved	CLK4	57396	upregulated	Hydrogen Peroxide results in increased expression of CLK4 mRNA	5q35.3
Hydrogen peroxide	Approved Vet Approved	CLPB	81570	upregulated	Hydrogen Peroxide results in increased expression of CLPB mRNA	11q13.4
Hydrogen peroxide	Approved Vet Approved	COG6	57511	upregulated	Hydrogen Peroxide results in increased expression of COG6 mRNA	13q14.11
Hydrogen peroxide	Approved Vet Approved	COMT	1312	upregulated	Hydrogen Peroxide results in increased expression of COMT mRNA	22q11.21
Hydrogen peroxide	Approved Vet Approved	COQ4	51117	upregulated	Hydrogen Peroxide results in increased expression of COQ4 mRNA	9q34.11
Hydrogen peroxide	Approved Vet Approved	CPM	1368	upregulated	Hydrogen Peroxide results in increased expression of CPM mRNA	12q15
Hydrogen peroxide	Approved Vet Approved	CR1	1378	upregulated	Hydrogen Peroxide results in increased expression of CR1 mRNA	1q32.2
Hydrogen peroxide	Approved Vet Approved	CREB1	1385	downregulated	Hydrogen Peroxide results in decreased expression of CREB1 mRNA	2q33.3
Hydrogen peroxide	Approved Vet Approved	CREB5	9586	downregulated	Hydrogen Peroxide results in decreased expression of CREB5 mRNA	7p15.1-p14.3
Hydrogen peroxide	Approved Vet Approved	CREBZF	58487	upregulated	Hydrogen Peroxide results in increased expression of CREBZF mRNA	11q14.1
Hydrogen peroxide	Approved Vet Approved	CRLS1	54675	upregulated	Hydrogen Peroxide results in increased expression of CRLS1 mRNA	20p12.3
Hydrogen peroxide	Approved Vet Approved	CRY1	1407	downregulated	Hydrogen Peroxide results in decreased expression of CRY1 mRNA	12q23.3
Hydrogen peroxide	Approved Vet Approved	CTDP1	9150	downregulated	Hydrogen Peroxide results in decreased expression of CTDP1 mRNA	18q23
Hydrogen peroxide	Approved Vet Approved	CTSE	1510	upregulated	Hydrogen Peroxide results in increased expression of CTSE mRNA	1q32.1
Hydrogen peroxide	Approved Vet Approved	CUX1	1523	upregulated	Hydrogen Peroxide results in increased expression of CUX1 mRNA	7q22.1
Hydrogen peroxide	Approved Vet Approved	CWF19L2	143884	downregulated	Hydrogen Peroxide results in decreased expression of CWF19L2 mRNA	11q22.3
Hydrogen peroxide	Approved Vet Approved	CYSLTR1	10800	downregulated	Hydrogen Peroxide results in decreased expression of CYSLTR1 mRNA	Xq21.1
Hydrogen peroxide	Approved Vet Approved	DBF4	10926	upregulated	Hydrogen Peroxide results in increased expression of DBF4 mRNA	7q21.12
Hydrogen peroxide	Approved Vet Approved	DDX50	79009	upregulated	Hydrogen Peroxide results in increased expression of DDX50 mRNA	10q22.1
Hydrogen peroxide	Approved Vet Approved	DLG5	9231	upregulated	Hydrogen Peroxide results in increased expression of DLG5 mRNA	10q22.3
Hydrogen peroxide	Approved Vet Approved	DNAJA2	10294	downregulated	Hydrogen Peroxide results in decreased expression of DNAJA2 mRNA	16q11.2
Hydrogen peroxide	Approved Vet Approved	DPYSL3	1809	downregulated	Hydrogen Peroxide results in decreased expression of DPYSL3 mRNA	5q32
Hydrogen peroxide	Approved Vet Approved	DUS4L	11062	upregulated	Hydrogen Peroxide results in increased expression of DUS4L mRNA	7q22.3
Hydrogen peroxide	Approved Vet Approved	ELF1	1997	downregulated	Hydrogen Peroxide results in decreased expression of ELF1 mRNA	13q14.11
Hydrogen peroxide	Approved Vet Approved	ELP6	54859	upregulated	Hydrogen Peroxide results in increased expression of ELP6 mRNA	3p21.31
Hydrogen peroxide	Approved Vet Approved	EML6	400954	upregulated	Hydrogen Peroxide results in increased expression of EML6 mRNA	2p16.1
Hydrogen peroxide	Approved Vet Approved	ERV3-2	57612	downregulated	Hydrogen Peroxide results in decreased expression of ERV3-2 mRNA	7q33
Hydrogen peroxide	Approved Vet Approved	FAM118B	79607	upregulated	Hydrogen Peroxide results in increased expression of FAM118B mRNA	11q24.2
Hydrogen peroxide	Approved Vet Approved	FAM120A	23196	upregulated	Hydrogen Peroxide results in increased expression of FAM120A mRNA	9q22.31
Hydrogen peroxide	Approved Vet Approved	FAM122B	159090	upregulated	Hydrogen Peroxide results in increased expression of FAM122B mRNA	Xq26.3
Hydrogen peroxide	Approved Vet Approved	FAM208A	23272	upregulated	Hydrogen Peroxide results in increased expression of FAM208A mRNA	3p14.3
Hydrogen peroxide	Approved Vet Approved	FAM46A	55603	downregulated	Hydrogen Peroxide results in decreased expression of FAM46A mRNA	6q14.1
Hydrogen peroxide	Approved Vet Approved	FAM46C	54855	downregulated	Hydrogen Peroxide results in decreased expression of FAM46C mRNA	1p12
Hydrogen peroxide	Approved Vet Approved	FAM76B	143684	downregulated	Hydrogen Peroxide results in decreased expression of FAM76B mRNA	11q21
Hydrogen peroxide	Approved Vet Approved	FBXL17	64839	upregulated	Hydrogen Peroxide results in increased expression of FBXL17 mRNA	5q21.3
Hydrogen peroxide	Approved Vet Approved	FBXO8	26269	downregulated	Hydrogen Peroxide results in decreased expression of FBXO8 mRNA	4q34.1
Hydrogen peroxide	Approved Vet Approved	FGFR1OP2	26127	downregulated	Hydrogen Peroxide results in decreased expression of FGFR1OP2 mRNA	12p11.23
Hydrogen peroxide	Approved Vet Approved	FLOT2	2319	upregulated	Hydrogen Peroxide results in increased expression of FLOT2 mRNA	17q11.2
Hydrogen peroxide	Approved Vet Approved	FNTA	2339	upregulated	Hydrogen Peroxide results in increased expression of FNTA mRNA	8p11.21
Hydrogen peroxide	Approved Vet Approved	FPGT	8790	upregulated	Hydrogen Peroxide results in increased expression of FPGT mRNA	1p31.1
Hydrogen peroxide	Approved Vet Approved	G2E3	55632	upregulated	Hydrogen Peroxide results in increased expression of G2E3 mRNA	14q12
Hydrogen peroxide	Approved Vet Approved	GCLM	2730	downregulated	Hydrogen Peroxide results in decreased expression of GCLM mRNA	1p22.1
Hydrogen peroxide	Approved Vet Approved	GFM2	84340	upregulated	Hydrogen Peroxide results in increased expression of GFM2 mRNA	5q13.3
Hydrogen peroxide	Approved Vet Approved	GGPS1	9453	downregulated	Hydrogen Peroxide results in decreased expression of GGPS1 mRNA	1q42.3
Hydrogen peroxide	Approved Vet Approved	GNB5	10681	downregulated	Hydrogen Peroxide results in decreased expression of GNB5 mRNA	15q21.2
Hydrogen peroxide	Approved Vet Approved	GOLGA4	2803	downregulated	Hydrogen Peroxide results in decreased expression of GOLGA4 mRNA	3p22.2
Hydrogen peroxide	Approved Vet Approved	GPR34	2857	upregulated	Hydrogen Peroxide results in increased expression of GPR34 mRNA	Xp11.4
Hydrogen peroxide	Approved Vet Approved	GPRIN3	285513	upregulated	Hydrogen Peroxide results in increased expression of GPRIN3 mRNA	4q22.1
Hydrogen peroxide	Approved Vet Approved	GPT2	84706	upregulated	Hydrogen Peroxide results in increased expression of GPT2 mRNA	16q11.2
Hydrogen peroxide	Approved Vet Approved	GRK3	157	downregulated	Hydrogen Peroxide results in decreased expression of GRK3 mRNA	22q12.1
Hydrogen peroxide	Approved Vet Approved	HDDC2	51020	upregulated	Hydrogen Peroxide results in increased expression of HDDC2 mRNA	6q22.31
Hydrogen peroxide	Approved Vet Approved	HERC1	8925	upregulated	Hydrogen Peroxide results in increased expression of HERC1 mRNA	15q22.31
Hydrogen peroxide	Approved Vet Approved	HERPUD2	64224	downregulated	Hydrogen Peroxide results in decreased expression of HERPUD2 mRNA	7p14.2
Hydrogen peroxide	Approved Vet Approved	HIST1H1C	3006	downregulated	Hydrogen Peroxide results in decreased expression of HIST1H1C mRNA	6p22.2
Hydrogen peroxide	Approved Vet Approved	HNRNPUL2	221092	upregulated	Hydrogen Peroxide results in increased expression of HNRNPUL2 mRNA	11q12.3
Hydrogen peroxide	Approved Vet Approved	HOXA13	3209	upregulated	Hydrogen Peroxide results in increased expression of HOXA13 mRNA	7p15.2
Hydrogen peroxide	Approved Vet Approved	HTR1E	3354	upregulated	Hydrogen Peroxide results in increased expression of HTR1E mRNA	6q14.3
Hydrogen peroxide	Approved Vet Approved	ILVBL	10994	upregulated	Hydrogen Peroxide results in increased expression of ILVBL mRNA	19p13.12
Hydrogen peroxide	Approved Vet Approved	INPP5F	22876	upregulated	Hydrogen Peroxide results in increased expression of INPP5F mRNA	10q26.11
Hydrogen peroxide	Approved Vet Approved	INTS13	55726	upregulated	Hydrogen Peroxide results in increased expression of INTS13 mRNA	12p11.23
Hydrogen peroxide	Approved Vet Approved	IPP	3652	downregulated	Hydrogen Peroxide results in decreased expression of IPP mRNA	1p34.1
Hydrogen peroxide	Approved Vet Approved	ITFG1	81533	downregulated	Hydrogen Peroxide results in decreased expression of ITFG1 mRNA	16q12.1
Hydrogen peroxide	Approved Vet Approved	ITGB5	3693	upregulated	Hydrogen Peroxide results in increased expression of ITGB5 mRNA	3q21.2
Hydrogen peroxide	Approved Vet Approved	ITPR1	3708	upregulated	Hydrogen Peroxide results in increased expression of ITPR1 mRNA	3p26.1
Hydrogen peroxide	Approved Vet Approved	IWS1	55677	downregulated	Hydrogen Peroxide results in decreased expression of IWS1 mRNA	2q14.3
Hydrogen peroxide	Approved Vet Approved	JADE3	9767	downregulated	Hydrogen Peroxide results in decreased expression of JADE3 mRNA	Xp11.3
Hydrogen peroxide	Approved Vet Approved	JAK1	3716	downregulated	Hydrogen Peroxide results in decreased expression of JAK1 mRNA	1p31.3
Hydrogen peroxide	Approved Vet Approved	JARID2	3720	downregulated	Hydrogen Peroxide results in decreased expression of JARID2 mRNA	6p22.3
Hydrogen peroxide	Approved Vet Approved	JRKL	8690	upregulated	Hydrogen Peroxide results in increased expression of JRKL mRNA	11q21
Hydrogen peroxide	Approved Vet Approved	JUN	3725	downregulated	Hydrogen Peroxide results in decreased expression of JUN mRNA	1p32.1
Hydrogen peroxide	Approved Vet Approved	KAT14	57325	upregulated	Hydrogen Peroxide results in increased expression of KAT14 mRNA	20p11.23
Hydrogen peroxide	Approved Vet Approved	KCTD1	284252	downregulated	Hydrogen Peroxide results in decreased expression of KCTD1 mRNA	18q11.2
Hydrogen peroxide	Approved Vet Approved	KDM2A	22992	downregulated	Hydrogen Peroxide results in decreased expression of KDM2A mRNA	11q13.2
Hydrogen peroxide	Approved Vet Approved	KIAA1024	23251	upregulated	Hydrogen Peroxide results in increased expression of KIAA1024 mRNA	15q25.1
Hydrogen peroxide	Approved Vet Approved	KIAA1586	57691	downregulated	Hydrogen Peroxide results in decreased expression of KIAA1586 mRNA	6p12.1
Hydrogen peroxide	Approved Vet Approved	KIF3A	11127	upregulated	Hydrogen Peroxide results in increased expression of KIF3A mRNA	5q31.1
Hydrogen peroxide	Approved Vet Approved	KLF1	10661	upregulated	Hydrogen Peroxide results in increased expression of KLF1 mRNA	19p13.13
Hydrogen peroxide	Approved Vet Approved	KLF10	7071	downregulated	Hydrogen Peroxide results in decreased expression of KLF10 mRNA	8q22.3
Hydrogen peroxide	Approved Vet Approved	KLF9	687	downregulated	Hydrogen Peroxide results in decreased expression of KLF9 mRNA	9q21.12
Hydrogen peroxide	Approved Vet Approved	KLHL7	55975	upregulated	Hydrogen Peroxide results in increased expression of KLHL7 mRNA	7p15.3
Hydrogen peroxide	Approved Vet Approved	KLHL8	57563	upregulated	Hydrogen Peroxide results in increased expression of KLHL8 mRNA	4q22.1
Hydrogen peroxide	Approved Vet Approved	KRT86	3892	upregulated	Hydrogen Peroxide results in increased expression of KRT86 mRNA	12q13
Hydrogen peroxide	Approved Vet Approved	KYNU	8942	downregulated	Hydrogen Peroxide results in decreased expression of KYNU mRNA	2q22.2
Hydrogen peroxide	Approved Vet Approved	LATS1	9113	downregulated	Hydrogen Peroxide results in decreased expression of LATS1 mRNA	6q25.1
Hydrogen peroxide	Approved Vet Approved	LDAH	60526	upregulated	Hydrogen Peroxide results in increased expression of LDAH mRNA	2p24.1
Hydrogen peroxide	Approved Vet Approved	LNPK	80856	upregulated	Hydrogen Peroxide results in increased expression of LNPK mRNA	2q31.1
Hydrogen peroxide	Approved Vet Approved	LSM6	11157	upregulated	Hydrogen Peroxide results in increased expression of LSM6 mRNA	4q31.22
Hydrogen peroxide	Approved Vet Approved	LUC7L	55692	upregulated	Hydrogen Peroxide results in increased expression of LUC7L mRNA	16p13.3
Hydrogen peroxide	Approved Vet Approved	LY9	4063	downregulated	Hydrogen Peroxide results in decreased expression of LY9 mRNA	1q23.3
Hydrogen peroxide	Approved Vet Approved	LYSMD3	116068	upregulated	Hydrogen Peroxide results in increased expression of LYSMD3 mRNA	5q14.3
Hydrogen peroxide	Approved Vet Approved	MAN1A2	10905	downregulated	Hydrogen Peroxide results in decreased expression of MAN1A2 mRNA	1p12
Hydrogen peroxide	Approved Vet Approved	MAP3K2	10746	upregulated	Hydrogen Peroxide results in increased expression of MAP3K2 mRNA	2q14.3
Hydrogen peroxide	Approved Vet Approved	MAPKAP1	79109	downregulated	Hydrogen Peroxide results in decreased expression of MAPKAP1 mRNA	9q33.3
Hydrogen peroxide	Approved Vet Approved	MBD5	55777	downregulated	Hydrogen Peroxide results in decreased expression of MBD5 mRNA	2q23.2
Hydrogen peroxide	Approved Vet Approved	METTL7A	25840	downregulated	Hydrogen Peroxide results in decreased expression of METTL7A mRNA	12q13.12
Hydrogen peroxide	Approved Vet Approved	MGST3	4259	upregulated	Hydrogen Peroxide results in increased expression of MGST3 mRNA	1q24.1
Hydrogen peroxide	Approved Vet Approved	MMAB	326625	upregulated	Hydrogen Peroxide results in increased expression of MMAB mRNA	12q24.11
Hydrogen peroxide	Approved Vet Approved	MMD	23531	upregulated	Hydrogen Peroxide results in increased expression of MMD mRNA	17q22
Hydrogen peroxide	Approved Vet Approved	MMP19	4327	downregulated	Hydrogen Peroxide results in decreased expression of MMP19 mRNA	12q13.2
Hydrogen peroxide	Approved Vet Approved	MOCS2	4338	upregulated	Hydrogen Peroxide results in increased expression of MOCS2 mRNA	5q11.2
Hydrogen peroxide	Approved Vet Approved	MRPL19	9801	upregulated	Hydrogen Peroxide results in increased expression of MRPL19 mRNA	2p12
Hydrogen peroxide	Approved Vet Approved	MRPL4	51073	upregulated	Hydrogen Peroxide results in increased expression of MRPL4 mRNA	19p13.2
Hydrogen peroxide	Approved Vet Approved	MRPS14	63931	upregulated	Hydrogen Peroxide results in increased expression of MRPS14 mRNA	1q25.1
Hydrogen peroxide	Approved Vet Approved	MTG2	26164	upregulated	Hydrogen Peroxide results in increased expression of MTG2 mRNA	20q13.33
Hydrogen peroxide	Approved Vet Approved	MUM1	84939	upregulated	Hydrogen Peroxide results in increased expression of MUM1 mRNA	19p13.3
Hydrogen peroxide	Approved Vet Approved	MYO1C	4641	upregulated	Hydrogen Peroxide results in increased expression of MYO1C mRNA	17p13.3
Hydrogen peroxide	Approved Vet Approved	NBPF3	84224	upregulated	Hydrogen Peroxide results in increased expression of NBPF3 mRNA	1p36.12
Hydrogen peroxide	Approved Vet Approved	NDUFAF7	55471	upregulated	Hydrogen Peroxide results in increased expression of NDUFAF7 mRNA	2p22.2
Hydrogen peroxide	Approved Vet Approved	NEK1	4750	upregulated	Hydrogen Peroxide results in increased expression of NEK1 mRNA	4q33
Hydrogen peroxide	Approved Vet Approved	NHLRC2	374354	upregulated	Hydrogen Peroxide results in increased expression of NHLRC2 mRNA	10q25.3
Hydrogen peroxide	Approved Vet Approved	NMD3	51068	upregulated	Hydrogen Peroxide results in increased expression of NMD3 mRNA	3q26.1
Hydrogen peroxide	Approved Vet Approved	NME1	4830	upregulated	Hydrogen Peroxide results in increased expression of NME1 mRNA	17q21.33
Hydrogen peroxide	Approved Vet Approved	NMNAT3	349565	upregulated	Hydrogen Peroxide results in increased expression of NMNAT3 mRNA	3q23
Hydrogen peroxide	Approved Vet Approved	NUP160	23279	downregulated	Hydrogen Peroxide results in decreased expression of NUP160 mRNA	11p11.2
Hydrogen peroxide	Approved Vet Approved	NUP160	23279	upregulated	Hydrogen Peroxide results in increased expression of NUP160 mRNA	11p11.2
Hydrogen peroxide	Approved Vet Approved	NUP58	9818	downregulated	Hydrogen Peroxide results in decreased expression of NUP58 mRNA	13q12.13
Hydrogen peroxide	Approved Vet Approved	PARG	8505	upregulated	Hydrogen Peroxide results in increased expression of PARG mRNA	10q11.23
Hydrogen peroxide	Approved Vet Approved	PBLD	64081	downregulated	Hydrogen Peroxide results in decreased expression of PBLD mRNA	10q21.3
Hydrogen peroxide	Approved Vet Approved	PCM1	5108	upregulated	Hydrogen Peroxide results in increased expression of PCM1 mRNA	8p22
Hydrogen peroxide	Approved Vet Approved	PCMTD2	55251	upregulated	Hydrogen Peroxide results in increased expression of PCMTD2 mRNA	20q13.33
Hydrogen peroxide	Approved Vet Approved	PDCD2	5134	downregulated	Hydrogen Peroxide results in decreased expression of PDCD2 mRNA	6q27
Hydrogen peroxide	Approved Vet Approved	PDLIM5	10611	upregulated	Hydrogen Peroxide results in increased expression of PDLIM5 mRNA	4q22.3
Hydrogen peroxide	Approved Vet Approved	PDP1	54704	upregulated	Hydrogen Peroxide results in increased expression of PDP1 mRNA	8q22.1
Hydrogen peroxide	Approved Vet Approved	PGM2	55276	upregulated	Hydrogen Peroxide results in increased expression of PGM2 mRNA	4p14
Hydrogen peroxide	Approved Vet Approved	PHAX	51808	upregulated	Hydrogen Peroxide results in increased expression of PHAX mRNA	5q23.2
Hydrogen peroxide	Approved Vet Approved	PHF20L1	51105	downregulated	Hydrogen Peroxide results in decreased expression of PHF20L1 mRNA	8q24.22
Hydrogen peroxide	Approved Vet Approved	PHF6	84295	upregulated	Hydrogen Peroxide results in increased expression of PHF6 mRNA	Xq26.2
Hydrogen peroxide	Approved Vet Approved	PIGM	93183	upregulated	Hydrogen Peroxide results in increased expression of PIGM mRNA	1q23.2
Hydrogen peroxide	Approved Vet Approved	PIP4K2A	5305	upregulated	Hydrogen Peroxide results in increased expression of PIP4K2A mRNA	10p12.2
Hydrogen peroxide	Approved Vet Approved	PLEC	5339	upregulated	Hydrogen Peroxide results in increased expression of PLEC mRNA	8q24.3
Hydrogen peroxide	Approved Vet Approved	PLEKHA1	59338	upregulated	Hydrogen Peroxide results in increased expression of PLEKHA1 mRNA	10q26.13
Hydrogen peroxide	Approved Vet Approved	PLEKHA8	84725	upregulated	Hydrogen Peroxide results in increased expression of PLEKHA8 mRNA	7p14.3
Hydrogen peroxide	Approved Vet Approved	POLH	5429	downregulated	Hydrogen Peroxide results in decreased expression of POLH mRNA	6p21.1
Hydrogen peroxide	Approved Vet Approved	PRAM1	84106	upregulated	Hydrogen Peroxide results in increased expression of PRAM1 mRNA	19p13.2
Hydrogen peroxide	Approved Vet Approved	PREPL	9581	upregulated	Hydrogen Peroxide results in increased expression of PREPL mRNA	2p21
Hydrogen peroxide	Approved Vet Approved	PRKAA1	5562	downregulated	Hydrogen Peroxide results in decreased expression of PRKAA1 mRNA	5p13.1
Hydrogen peroxide	Approved Vet Approved	PRLR	5618	downregulated	Hydrogen Peroxide results in decreased expression of PRLR mRNA	5p13.2
Hydrogen peroxide	Approved Vet Approved	PRRX1	5396	upregulated	Hydrogen Peroxide results in increased expression of PRRX1 mRNA	1q24.2
Hydrogen peroxide	Approved Vet Approved	PTPN2	5771	upregulated	Hydrogen Peroxide results in increased expression of PTPN2 mRNA	18p11.21
Hydrogen peroxide	Approved Vet Approved	PTPN22	26191	upregulated	Hydrogen Peroxide results in increased expression of PTPN22 mRNA	1p13.2
Hydrogen peroxide	Approved Vet Approved	RAB3GAP2	25782	upregulated	Hydrogen Peroxide results in increased expression of RAB3GAP2 mRNA	1q41
Hydrogen peroxide	Approved Vet Approved	RABGAP1L	9910	upregulated	Hydrogen Peroxide results in increased expression of RABGAP1L mRNA	1q25.1
Hydrogen peroxide	Approved Vet Approved	RAD1	5810	downregulated	Hydrogen Peroxide results in decreased expression of RAD1 mRNA	5p13.2
Hydrogen peroxide	Approved Vet Approved	RAD50	10111	upregulated	Hydrogen Peroxide results in increased expression of RAD50 mRNA	5q31.1
Hydrogen peroxide	Approved Vet Approved	RASAL2	9462	downregulated	Hydrogen Peroxide results in decreased expression of RASAL2 mRNA	1q25.2
Hydrogen peroxide	Approved Vet Approved	RBL2	5934	upregulated	Hydrogen Peroxide results in increased expression of RBL2 mRNA	16q12.2
Hydrogen peroxide	Approved Vet Approved	RBM15	64783	downregulated	Hydrogen Peroxide results in decreased expression of RBM15 mRNA	1p13.3
Hydrogen peroxide	Approved Vet Approved	RBM33	155435	downregulated	Hydrogen Peroxide results in decreased expression of RBM33 mRNA	7q36.3
Hydrogen peroxide	Approved Vet Approved	RBM48	84060	downregulated	Hydrogen Peroxide results in decreased expression of RBM48 mRNA	7q21.2
Hydrogen peroxide	Approved Vet Approved	RDH14	57665	downregulated	Hydrogen Peroxide results in decreased expression of RDH14 mRNA	2p24.2
Hydrogen peroxide	Approved Vet Approved	RENBP	5973	upregulated	Hydrogen Peroxide results in increased expression of RENBP mRNA	Xq28
Hydrogen peroxide	Approved Vet Approved	RFTN1	23180	upregulated	Hydrogen Peroxide results in increased expression of RFTN1 mRNA	3p24.3
Hydrogen peroxide	Approved Vet Approved	RIC1	57589	upregulated	Hydrogen Peroxide results in increased expression of RIC1 mRNA	9p24.1
Hydrogen peroxide	Approved Vet Approved	RIOK3	8780	downregulated	Hydrogen Peroxide results in decreased expression of RIOK3 mRNA	18q11.2
Hydrogen peroxide	Approved Vet Approved	RLN1	6013	downregulated	Hydrogen Peroxide results in decreased expression of RLN1 mRNA	9p24.1
Hydrogen peroxide	Approved Vet Approved	RMND1	55005	upregulated	Hydrogen Peroxide results in increased expression of RMND1 mRNA	6q25.1
Hydrogen peroxide	Approved Vet Approved	RNF165	494470	upregulated	Hydrogen Peroxide results in increased expression of RNF165 mRNA	18q21.1
Hydrogen peroxide	Approved Vet Approved	RNF32	140545	downregulated	Hydrogen Peroxide results in decreased expression of RNF32 mRNA	7q36.3
Hydrogen peroxide	Approved Vet Approved	RP2	6102	downregulated	Hydrogen Peroxide results in decreased expression of RP2 mRNA	Xp11.3
Hydrogen peroxide	Approved Vet Approved	RPE	6120	upregulated	Hydrogen Peroxide results in increased expression of RPE mRNA	2q34
Hydrogen peroxide	Approved Vet Approved	S100A6	6277	downregulated	Hydrogen Peroxide results in decreased expression of S100A6 mRNA	1q21.3
Hydrogen peroxide	Approved Vet Approved	SEC22A	26984	upregulated	Hydrogen Peroxide results in increased expression of SEC22A mRNA	3q21.1
Hydrogen peroxide	Approved Vet Approved	SEMA4D	10507	upregulated	Hydrogen Peroxide results in increased expression of SEMA4D mRNA	9q22.2
Hydrogen peroxide	Approved Vet Approved	SERAC1	84947	upregulated	Hydrogen Peroxide results in increased expression of SERAC1 mRNA	6q25.3
Hydrogen peroxide	Approved Vet Approved	SETD2	29072	downregulated	Hydrogen Peroxide results in decreased expression of SETD2 mRNA	3p21.31
Hydrogen peroxide	Approved Vet Approved	SFR1	119392	downregulated	Hydrogen Peroxide results in decreased expression of SFR1 mRNA	10q25.1
Hydrogen peroxide	Approved Vet Approved	SFXN2	118980	upregulated	Hydrogen Peroxide results in increased expression of SFXN2 mRNA	10q24.32
Hydrogen peroxide	Approved Vet Approved	SFXN4	119559	downregulated	Hydrogen Peroxide results in decreased expression of SFXN4 mRNA	10q26.11
Hydrogen peroxide	Approved Vet Approved	SLC12A8	84561	downregulated	Hydrogen Peroxide results in decreased expression of SLC12A8 mRNA	3q21.2
Hydrogen peroxide	Approved Vet Approved	SLC25A16	8034	upregulated	Hydrogen Peroxide results in increased expression of SLC25A16 mRNA	10q21.3
Hydrogen peroxide	Approved Vet Approved	SLC25A51	92014	downregulated	Hydrogen Peroxide results in decreased expression of SLC25A51 mRNA	9p13.2-p13.1
Hydrogen peroxide	Approved Vet Approved	SLC5A3	6526	upregulated	Hydrogen Peroxide results in increased expression of SLC5A3 mRNA	21q22.11
Hydrogen peroxide	Approved Vet Approved	SLC7A11	23657	downregulated	Hydrogen Peroxide results in decreased expression of SLC7A11 mRNA	4q28.3
Hydrogen peroxide	Approved Vet Approved	SMARCA5	8467	downregulated	Hydrogen Peroxide results in decreased expression of SMARCA5 mRNA	4q31.21
Hydrogen peroxide	Approved Vet Approved	SNAPC3	6619	upregulated	Hydrogen Peroxide results in increased expression of SNAPC3 mRNA	9p22.3
Hydrogen peroxide	Approved Vet Approved	SNRPN	6638	upregulated	Hydrogen Peroxide results in increased expression of SNRPN mRNA	15q11.2
Hydrogen peroxide	Approved Vet Approved	SOCS5	9655	downregulated	Hydrogen Peroxide results in decreased expression of SOCS5 mRNA	2p21
Hydrogen peroxide	Approved Vet Approved	SOCS5	9655	upregulated	Hydrogen Peroxide results in increased expression of SOCS5 mRNA	2p21
Hydrogen peroxide	Approved Vet Approved	SOS1	6654	downregulated	Hydrogen Peroxide results in decreased expression of SOS1 mRNA	2p22.1
Hydrogen peroxide	Approved Vet Approved	SSR3	6747	downregulated	Hydrogen Peroxide results in decreased expression of SSR3 mRNA	3q25.31
Hydrogen peroxide	Approved Vet Approved	STIM2	57620	upregulated	Hydrogen Peroxide results in increased expression of STIM2 mRNA	4p15.2
Hydrogen peroxide	Approved Vet Approved	STK17A	9263	downregulated	Hydrogen Peroxide results in decreased expression of STK17A mRNA	7p13
Hydrogen peroxide	Approved Vet Approved	STRADB	55437	upregulated	Hydrogen Peroxide results in increased expression of STRADB mRNA	2q33.1
Hydrogen peroxide	Approved Vet Approved	STRN	6801	upregulated	Hydrogen Peroxide results in increased expression of STRN mRNA	2p22.2
Hydrogen peroxide	Approved Vet Approved	SUMF1	285362	upregulated	Hydrogen Peroxide results in increased expression of SUMF1 mRNA	3p26.1
Hydrogen peroxide	Approved Vet Approved	SUZ12	23512	downregulated	Hydrogen Peroxide results in decreased expression of SUZ12 mRNA	17q11.2
Hydrogen peroxide	Approved Vet Approved	TAF5	6877	upregulated	Hydrogen Peroxide results in increased expression of TAF5 mRNA	10q24.33
Hydrogen peroxide	Approved Vet Approved	TASP1	55617	downregulated	Hydrogen Peroxide results in decreased expression of TASP1 mRNA	20p12.1
Hydrogen peroxide	Approved Vet Approved	TASP1	55617	upregulated	Hydrogen Peroxide results in increased expression of TASP1 mRNA	20p12.1
Hydrogen peroxide	Approved Vet Approved	TBCCD1	55171	upregulated	Hydrogen Peroxide results in increased expression of TBCCD1 mRNA	3q27.3
Hydrogen peroxide	Approved Vet Approved	THYN1	29087	upregulated	Hydrogen Peroxide results in increased expression of THYN1 mRNA	11q25
Hydrogen peroxide	Approved Vet Approved	TMCC1	23023	upregulated	Hydrogen Peroxide results in increased expression of TMCC1 mRNA	3q22.1
Hydrogen peroxide	Approved Vet Approved	TMEM106B	54664	upregulated	Hydrogen Peroxide results in increased expression of TMEM106B mRNA	7p21.3
Hydrogen peroxide	Approved Vet Approved	TMEM140	55281	downregulated	Hydrogen Peroxide results in decreased expression of TMEM140 mRNA	7q33
Hydrogen peroxide	Approved Vet Approved	TMEM184C	55751	downregulated	Hydrogen Peroxide results in decreased expression of TMEM184C mRNA	4q31.23
Hydrogen peroxide	Approved Vet Approved	TMEM50B	757	upregulated	Hydrogen Peroxide results in increased expression of TMEM50B mRNA	21q22.11
Hydrogen peroxide	Approved Vet Approved	TMEM65	157378	downregulated	Hydrogen Peroxide results in decreased expression of TMEM65 mRNA	8q24.13
Hydrogen peroxide	Approved Vet Approved	TMTC2	160335	upregulated	Hydrogen Peroxide results in increased expression of TMTC2 mRNA	12q21.31
Hydrogen peroxide	Approved Vet Approved	TNFRSF21	27242	downregulated	Hydrogen Peroxide results in decreased expression of TNFRSF21 mRNA	6p12.3
Hydrogen peroxide	Approved Vet Approved	TNFSF4	7292	upregulated	Hydrogen Peroxide results in increased expression of TNFSF4 mRNA	1q25.1
Hydrogen peroxide	Approved Vet Approved	TNRC6B	23112	downregulated	Hydrogen Peroxide results in decreased expression of TNRC6B mRNA	22q13.1
Hydrogen peroxide	Approved Vet Approved	TOR1AIP2	163590	upregulated	Hydrogen Peroxide results in increased expression of TOR1AIP2 mRNA	1q25.2
Hydrogen peroxide	Approved Vet Approved	TPR	7175	upregulated	Hydrogen Peroxide results in increased expression of TPR mRNA	1q31.1
Hydrogen peroxide	Approved Vet Approved	TRAPPC13	80006	upregulated	Hydrogen Peroxide results in increased expression of TRAPPC13 mRNA	5q12.3
Hydrogen peroxide	Approved Vet Approved	TRIM3	10612	downregulated	Hydrogen Peroxide results in decreased expression of TRIM3 mRNA	11p15.4
Hydrogen peroxide	Approved Vet Approved	TRIO	7204	downregulated	Hydrogen Peroxide results in decreased expression of TRIO mRNA	5p15.2
Hydrogen peroxide	Approved Vet Approved	TRMT61A	115708	upregulated	Hydrogen Peroxide results in increased expression of TRMT61A mRNA	14q32
Hydrogen peroxide	Approved Vet Approved	TSC22D3	1831	upregulated	Hydrogen Peroxide results in increased expression of TSC22D3 mRNA	Xq22.3
Hydrogen peroxide	Approved Vet Approved	TSEN15	116461	upregulated	Hydrogen Peroxide results in increased expression of TSEN15 mRNA	1q25.3
Hydrogen peroxide	Approved Vet Approved	TTC3	7267	upregulated	Hydrogen Peroxide results in increased expression of TTC3 mRNA	21q22.13
Hydrogen peroxide	Approved Vet Approved	TXNRD1	7296	downregulated	Hydrogen Peroxide results in decreased expression of TXNRD1 mRNA	12q23.3
Hydrogen peroxide	Approved Vet Approved	UBE2D1	7321	downregulated	Hydrogen Peroxide results in decreased expression of UBE2D1 mRNA	10q21.1
Hydrogen peroxide	Approved Vet Approved	UBR5	51366	upregulated	Hydrogen Peroxide results in increased expression of UBR5 mRNA	8q22.3
Hydrogen peroxide	Approved Vet Approved	UCHL5	51377	upregulated	Hydrogen Peroxide results in increased expression of UCHL5 mRNA	1q31.2
Hydrogen peroxide	Approved Vet Approved	UCKL1	54963	upregulated	Hydrogen Peroxide results in increased expression of UCKL1 mRNA	20q13.33
Hydrogen peroxide	Approved Vet Approved	UQCRC2	7385	upregulated	Hydrogen Peroxide results in increased expression of UQCRC2 mRNA	16p12.2
Hydrogen peroxide	Approved Vet Approved	USP33	23032	downregulated	Hydrogen Peroxide results in decreased expression of USP33 mRNA	1p31.1
Hydrogen peroxide	Approved Vet Approved	UTP18	51096	upregulated	Hydrogen Peroxide results in increased expression of UTP18 mRNA	17q21.33
Hydrogen peroxide	Approved Vet Approved	VPS13C	54832	upregulated	Hydrogen Peroxide results in increased expression of VPS13C mRNA	15q22.2
Hydrogen peroxide	Approved Vet Approved	VPS54	51542	upregulated	Hydrogen Peroxide results in increased expression of VPS54 mRNA	2p15-p14
Hydrogen peroxide	Approved Vet Approved	WASF1	8936	downregulated	Hydrogen Peroxide results in decreased expression of WASF1 mRNA	6q21
Hydrogen peroxide	Approved Vet Approved	WDFY2	115825	downregulated	Hydrogen Peroxide results in decreased expression of WDFY2 mRNA	13q14.3
Hydrogen peroxide	Approved Vet Approved	WDR20	91833	downregulated	Hydrogen Peroxide results in decreased expression of WDR20 mRNA	14q32.31
Hydrogen peroxide	Approved Vet Approved	WDR33	55339	downregulated	Hydrogen Peroxide results in decreased expression of WDR33 mRNA	2q14.3
Hydrogen peroxide	Approved Vet Approved	WDR5	11091	upregulated	Hydrogen Peroxide results in increased expression of WDR5 mRNA	9q34.2
Hydrogen peroxide	Approved Vet Approved	XPO4	64328	upregulated	Hydrogen Peroxide results in increased expression of XPO4 mRNA	13q12.11
Hydrogen peroxide	Approved Vet Approved	YEATS2	55689	downregulated	Hydrogen Peroxide results in decreased expression of YEATS2 mRNA	3q27.1
Hydrogen peroxide	Approved Vet Approved	YIPF4	84272	downregulated	Hydrogen Peroxide results in decreased expression of YIPF4 mRNA	2p22.3
Hydrogen peroxide	Approved Vet Approved	ZBTB14	7541	upregulated	Hydrogen Peroxide results in increased expression of ZBTB14 mRNA	18p11.31
Hydrogen peroxide	Approved Vet Approved	ZCCHC2	54877	downregulated	Hydrogen Peroxide results in decreased expression of ZCCHC2 mRNA	18q21.33
Hydrogen peroxide	Approved Vet Approved	ZFX	7543	upregulated	Hydrogen Peroxide results in increased expression of ZFX mRNA	Xp22.11
Hydrogen peroxide	Approved Vet Approved	ZNF174	7727	upregulated	Hydrogen Peroxide results in increased expression of ZNF174 mRNA	16p13.3
Hydrogen peroxide	Approved Vet Approved	ZNF236	7776	downregulated	Hydrogen Peroxide results in decreased expression of ZNF236 mRNA	18q22-q23
Hydrogen peroxide	Approved Vet Approved	ZNF292	23036	downregulated	Hydrogen Peroxide results in decreased expression of ZNF292 mRNA	6q14.3
Hydrogen peroxide	Approved Vet Approved	ZNF41	7592	upregulated	Hydrogen Peroxide results in increased expression of ZNF41 mRNA	Xp11.3
Hydrogen peroxide	Approved Vet Approved	ZNF45	7596	upregulated	Hydrogen Peroxide results in increased expression of ZNF45 mRNA	19q13.2
Hydrogen peroxide	Approved Vet Approved	ZNF567	163081	downregulated	Hydrogen Peroxide results in decreased expression of ZNF567 mRNA	19q13.12
Hydrogen peroxide	Approved Vet Approved	ZNF639	51193	upregulated	Hydrogen Peroxide results in increased expression of ZNF639 mRNA	3q26.33
Hydrogen peroxide	Approved Vet Approved	ZNF655	79027	downregulated	Hydrogen Peroxide results in decreased expression of ZNF655 mRNA	7q22.1
Hydrogen peroxide	Approved Vet Approved	ZNF681	148213	upregulated	Hydrogen Peroxide results in increased expression of ZNF681 mRNA	19p12
Hydrogen peroxide	Approved Vet Approved	ZNHIT6	54680	upregulated	Hydrogen Peroxide results in increased expression of ZNHIT6 mRNA	1p22.3
Hydrogen peroxide	Approved Vet Approved	ZRSR2	8233	downregulated	Hydrogen Peroxide results in decreased expression of ZRSR2 mRNA	Xp22.2
Theophylline	Approved	ADAD1	132612	downregulated	Theophylline results in decreased expression of ADAD1 mRNA	4q27
Theophylline	Approved	AGFG1	3267	upregulated	Theophylline results in increased expression of AGFG1 mRNA	2q36.3
Theophylline	Approved	AKT1S1	84335	upregulated	Theophylline results in increased expression of AKT1S1 mRNA	19q13.33
Theophylline	Approved	ANKDD1A	348094	upregulated	Theophylline results in increased expression of ANKDD1A mRNA	15q22.31
Theophylline	Approved	ANKRD44	91526	upregulated	Theophylline results in increased expression of ANKRD44 mRNA	2q33.1
Theophylline	Approved	AOC1	26	downregulated	Theophylline results in decreased expression of AOC1 mRNA	7q36.1
Theophylline	Approved	ARHGAP15	55843	upregulated	Theophylline results in increased expression of ARHGAP15 mRNA	2q22.2-q22.3
Theophylline	Approved	ATG3	64422	upregulated	Theophylline results in increased expression of ATG3 mRNA	3q13.2
Theophylline	Approved	ATP5S	27109	downregulated	Theophylline results in decreased expression of ATP5S mRNA	14q21.3
Theophylline	Approved	AZI2	64343	downregulated	Theophylline results in decreased expression of AZI2 mRNA	3p24.1
Theophylline	Approved	BPTF	2186	downregulated	Theophylline results in decreased expression of BPTF mRNA	17q24.2
Theophylline	Approved	CAMK2D	817	downregulated	Theophylline results in decreased expression of CAMK2D mRNA	4q26
Theophylline	Approved	CAPRIN1	4076	upregulated	Theophylline results in increased expression of CAPRIN1 mRNA	11p13
Theophylline	Approved	CCDC181	57821	downregulated	Theophylline results in decreased expression of CCDC181 mRNA	1q24.2
Theophylline	Approved	CEP290	80184	downregulated	Theophylline results in decreased expression of CEP290 mRNA	12q21.32
Theophylline	Approved	CFAP97	57587	upregulated	Theophylline results in increased expression of CFAP97 mRNA	4q35.1
Theophylline	Approved	CLEC16A	23274	downregulated	Theophylline results in decreased expression of CLEC16A mRNA	16p13.13
Theophylline	Approved	CLEC4F	165530	downregulated	Theophylline results in decreased expression of CLEC4F mRNA	2p13.3
Theophylline	Approved	CLPB	81570	upregulated	Theophylline results in increased expression of CLPB mRNA	11q13.4
Theophylline	Approved	CTRL	1506	upregulated	Theophylline results in increased expression of CTRL mRNA	16q22.1
Theophylline	Approved	CYSLTR1	10800	downregulated	Theophylline results in decreased expression of CYSLTR1 mRNA	Xq21.1
Theophylline	Approved	DRD5	1816	upregulated	Theophylline results in increased expression of DRD5 mRNA	4p16.1
Theophylline	Approved	EARS2	124454	upregulated	Theophylline results in increased expression of EARS2 mRNA	16p12.2
Theophylline	Approved	EIF3B	8662	upregulated	Theophylline results in increased expression of EIF3B mRNA	7p22.3
Theophylline	Approved	EPS15	2060	downregulated	Theophylline results in decreased expression of EPS15 mRNA	1p32.3
Theophylline	Approved	EYA3	2140	upregulated	Theophylline results in increased expression of EYA3 mRNA	1p35.3
Theophylline	Approved	FSD1L	83856	upregulated	Theophylline results in increased expression of FSD1L mRNA	9q31.2
Theophylline	Approved	GKAP1	80318	upregulated	Theophylline results in increased expression of GKAP1 mRNA	9q21.32
Theophylline	Approved	GLRX3	10539	upregulated	Theophylline results in increased expression of GLRX3 mRNA	10q26.3
Theophylline	Approved	GPR137C	283554	upregulated	Theophylline results in increased expression of GPR137C mRNA	14q22.1
Theophylline	Approved	GRK3	157	downregulated	Theophylline results in decreased expression of GRK3 mRNA	22q12.1
Theophylline	Approved	HIST1H2AK	8330	downregulated	Theophylline results in decreased expression of HIST1H2AK mRNA	6p22.1
Theophylline	Approved	HPS4	89781	downregulated	Theophylline results in decreased expression of HPS4 mRNA	22q12.1
Theophylline	Approved	HUS1	3364	downregulated	Theophylline results in decreased expression of HUS1 mRNA	7p12.3
Theophylline	Approved	IL6R	3570	downregulated	Theophylline results in decreased expression of IL6R mRNA	1q21.3
Theophylline	Approved	JADE1	79960	upregulated	Theophylline results in increased expression of JADE1 mRNA	4q28.2
Theophylline	Approved	KIR2DL3	3804	downregulated	Theophylline results in decreased expression of KIR2DL3 mRNA	19q13.42
Theophylline	Approved	LETM2	137994	downregulated	Theophylline results in decreased expression of LETM2 mRNA	8p11.23
Theophylline	Approved	LHFP	10186	downregulated	Theophylline results in decreased expression of LHFP mRNA	13q13.3-q14.11
Theophylline	Approved	MEF2A	4205	downregulated	Theophylline results in decreased expression of MEF2A mRNA	15q26.3
Theophylline	Approved	MILR1	284021	downregulated	Theophylline results in decreased expression of MILR1 mRNA	17q23.3
Theophylline	Approved	MON1B	22879	downregulated	Theophylline results in decreased expression of MON1B mRNA	16q23.1
Theophylline	Approved	MZT1	440145	downregulated	Theophylline results in decreased expression of MZT1 mRNA	13q21.33
Theophylline	Approved	NACC2	138151	upregulated	Theophylline results in increased expression of NACC2 mRNA	9q34.3
Theophylline	Approved	NREP	9315	downregulated	Theophylline results in decreased expression of NREP mRNA	5q22.1
Theophylline	Approved	NSUN4	387338	upregulated	Theophylline results in increased expression of NSUN4 mRNA	1p33
Theophylline	Approved	OR4N4	283694	upregulated	Theophylline results in increased expression of OR4N4 mRNA	15q11.2
Theophylline	Approved	PIPOX	51268	downregulated	Theophylline results in decreased expression of PIPOX mRNA	17q11.2
Theophylline	Approved	PKHD1	5314	downregulated	Theophylline results in decreased expression of PKHD1 mRNA	6p12.3-p12.2
Theophylline	Approved	PLRG1	5356	upregulated	Theophylline results in increased expression of PLRG1 mRNA	4q31.3
Theophylline	Approved	PRKAA1	5562	downregulated	Theophylline results in decreased expression of PRKAA1 mRNA	5p13.1
Theophylline	Approved	PROSER3	148137	upregulated	Theophylline results in increased expression of PROSER3 mRNA	19q13.12
Theophylline	Approved	PTPN2	5771	upregulated	Theophylline results in increased expression of PTPN2 mRNA	18p11.21
Theophylline	Approved	PTPRE	5791	upregulated	Theophylline results in increased expression of PTPRE mRNA	10q26.2
Theophylline	Approved	RAB11B	9230	upregulated	Theophylline results in increased expression of RAB11B mRNA	19p13.2
Theophylline	Approved	RANGRF	29098	upregulated	Theophylline results in increased expression of RANGRF mRNA	17p13
Theophylline	Approved	RASAL2	9462	downregulated	Theophylline results in decreased expression of RASAL2 mRNA	1q25.2
Theophylline	Approved	RDH10	157506	upregulated	Theophylline results in increased expression of RDH10 mRNA	8q21.11
Theophylline	Approved	RPS15	6209	downregulated	Theophylline results in decreased expression of RPS15 mRNA	19p13.3
Theophylline	Approved	SBSPON	157869	downregulated	Theophylline results in decreased expression of SBSPON mRNA	8q21.11
Theophylline	Approved	SETD2	29072	downregulated	Theophylline results in decreased expression of SETD2 mRNA	3p21.31
Theophylline	Approved	SIKE1	80143	upregulated	Theophylline results in increased expression of SIKE1 mRNA	1p13.2
Theophylline	Approved	SLC39A9	55334	upregulated	Theophylline results in increased expression of SLC39A9 mRNA	14q24.1
Theophylline	Approved	SMU1	55234	upregulated	Theophylline results in increased expression of SMU1 mRNA	9p21.1
Theophylline	Approved	SNHG4	724102	upregulated	Theophylline results in increased expression of SNHG4 mRNA	5q31.2
Theophylline	Approved	SPATS2L	26010	downregulated	Theophylline results in decreased expression of SPATS2L mRNA	2q33.1
Theophylline	Approved	SRR	63826	downregulated	Theophylline results in decreased expression of SRR mRNA	17p13.3
Theophylline	Approved	SSR3	6747	upregulated	Theophylline results in increased expression of SSR3 mRNA	3q25.31
Theophylline	Approved	TAF1A	9015	upregulated	Theophylline results in increased expression of TAF1A mRNA	1q41
Theophylline	Approved	TBCA	6902	upregulated	Theophylline results in increased expression of TBCA mRNA	5q14.1
Theophylline	Approved	TMEM19	55266	downregulated	Theophylline results in decreased expression of TMEM19 mRNA	12q21.1
Theophylline	Approved	TMEM63A	9725	downregulated	Theophylline results in decreased expression of TMEM63A mRNA	1q42.12
Theophylline	Approved	TMX3	54495	upregulated	Theophylline results in increased expression of TMX3 mRNA	18q22
Theophylline	Approved	TRMT10A	93587	downregulated	Theophylline results in decreased expression of TRMT10A mRNA	4q23
Theophylline	Approved	TRMT13	54482	upregulated	Theophylline results in increased expression of TRMT13 mRNA	1p21.2
Theophylline	Approved	TTC37	9652	downregulated	Theophylline results in decreased expression of TTC37 mRNA	5q15
Theophylline	Approved	UTP15	84135	upregulated	Theophylline results in increased expression of UTP15 mRNA	5q13.2
Theophylline	Approved	XIAP	331	upregulated	Theophylline results in increased expression of XIAP mRNA	Xq25
Theophylline	Approved	YAP1	10413	downregulated	Theophylline results in decreased expression of YAP1 mRNA	11q22.1
Theophylline	Approved	YIPF6	286451	upregulated	Theophylline results in increased expression of YIPF6 mRNA	Xq12-q13.1
Theophylline	Approved	YTHDC1	91746	upregulated	Theophylline results in increased expression of YTHDC1 mRNA	4q13.2
Theophylline	Approved	ZDHHC11	79844	downregulated	Theophylline results in decreased expression of ZDHHC11 mRNA	5p15.33
Theophylline	Approved	ZRSR2	8233	downregulated	Theophylline results in decreased expression of ZRSR2 mRNA	Xp22.2