Immobilized metal affinity chromatography and human serum proteomics.

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Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K

Immobilized metal affinity chromatography and human serum proteomics.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5.

PubMed ID

23896426 [ View in PubMed

]

Abstract

Metal-binding proteins have a pivotal role in normal and diseased states. We used metal affinity chromatography to enrich a fraction of human serum proteins on immobilized columns loaded with cadmium, nickel, zinc, copper, or lead in bis-Tris saline and these proteins were identified using LC-MS/MS. Tens of enriched proteins were identified and we here present the 20 most abundant for binding each metal. The binding of various proteins (complement C3, alpha-2-macroglobulin, serum albumin, apolipoprotein B-100, complement component 4B preproprotein, apolipoprotein A-I, serotransferrin, alpha-1-antitrypsin, ceruloplasmin, 47kDa protein, uncharacterized protein DKFZp686P15220, transthyretin, hemopexin, inter-alpha-trypsin inhibitor heavy chain H2, and histidine-rich glycoprotein) to different metals using immobilized metal affinity chromatography was compared to the literature. Although many metal-binding properties of these proteins have been confirmed, new metal-binding proteins have also been identified. The metal array use in the proteomic biomarker search technologies gives this data particular importance.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Copper	Afamin	Protein	Humans	Unknown	Not Available	Details
Copper	Alpha-1-antitrypsin	Protein	Humans	Unknown	Not Available	Details
Copper	Alpha-1B-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Copper	Alpha-2-antiplasmin	Protein	Humans	Unknown	Not Available	Details
Copper	Alpha-2-HS-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Copper	Angiotensinogen	Protein	Humans	Unknown	Not Available	Details
Copper	Antithrombin-III	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein A-I	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein A-II	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein A-IV	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein B receptor	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein C-II	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein C-III	Protein	Humans	Unknown	Not Available	Details
Copper	Apolipoprotein D	Protein	Humans	Unknown	Not Available	Details
Copper	Beta-2-glycoprotein 1	Protein	Humans	Unknown	Not Available	Details
Copper	C4b-binding protein alpha chain	Protein	Humans	Unknown	Not Available	Details
Copper	Clusterin	Protein	Humans	Unknown	Not Available	Details
Copper	Complement C1q subcomponent subunit C	Protein	Humans	Unknown	Not Available	Details
Copper	Complement C1s subcomponent	Protein	Humans	Unknown	Not Available	Details
Copper	Complement C3	Protein	Humans	Unknown	Not Available	Details
Copper	Complement C4-B	Protein	Humans	Unknown	Not Available	Details
Copper	Complement C5	Protein	Humans	Unknown	Not Available	Details
Copper	Complement component 1 Q subcomponent-binding protein, mitochondrial	Protein	Humans	Unknown	Not Available	Details
Copper	Complement component C8 beta chain	Protein	Humans	Unknown	Not Available	Details
Copper	Complement component C9	Protein	Humans	Unknown	Not Available	Details
Copper	Complement factor H	Protein	Humans	Unknown	Not Available	Details
Copper	Complement factor I	Protein	Humans	Unknown	Not Available	Details
Copper	Corticosteroid-binding globulin	Protein	Humans	Unknown	Not Available	Details
Copper	Gelsolin	Protein	Humans	Unknown	Not Available	Details
Copper	Hemoglobin subunit alpha	Protein	Humans	Unknown	Not Available	Details
Copper	Heparin cofactor 2	Protein	Humans	Unknown	Not Available	Details
Copper	Ig gamma-1 chain C region	Protein	Humans	Unknown	Not Available	Details
Copper	Ig gamma-4 chain C region	Protein	Humans	Unknown	Not Available	Details
Copper	Ig kappa chain V-III region GOL	Protein	Humans	Unknown	Not Available	Details
Copper	Insulin-like growth factor-binding protein complex acid labile subunit	Protein	Humans	Unknown	Not Available	Details
Copper	Inter-alpha-trypsin inhibitor heavy chain H2	Protein	Humans	Unknown	Not Available	Details
Copper	Kallistatin	Protein	Humans	Unknown	Not Available	Details
Copper	Keratin, type I cytoskeletal 10	Protein	Humans	Unknown	Not Available	Details
Copper	Keratin, type I cytoskeletal 9	Protein	Humans	Unknown	Not Available	Details
Copper	Keratin, type II cytoskeletal 1	Protein	Humans	Unknown	Not Available	Details
Copper	Keratin, type II cytoskeletal 2 epidermal	Protein	Humans	Unknown	Not Available	Details
Copper	Kininogen-1	Protein	Humans	Unknown	Not Available	Details
Copper	Leucine-rich alpha-2-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Copper	Lumican	Protein	Humans	Unknown	Not Available	Details
Copper	N-acetylmuramoyl-L-alanine amidase	Protein	Humans	Unknown	Not Available	Details
Copper	Pigment epithelium-derived factor	Protein	Humans	Unknown	Not Available	Details
Copper	Plasma protease C1 inhibitor	Protein	Humans	Unknown	Not Available	Details
Copper	Platelet basic protein	Protein	Humans	Unknown	Not Available	Details
Copper	Prothrombin	Protein	Humans	Unknown	Not Available	Details
Copper	Serum amyloid P-component	Protein	Humans	Unknown	Not Available	Details
Copper	Serum paraoxonase/arylesterase 1	Protein	Humans	Unknown	Not Available	Details
Copper	Tetranectin	Protein	Humans	Unknown	Not Available	Details
Copper	Thyroxine-binding globulin	Protein	Humans	Unknown	Not Available	Details
Copper	Transthyretin	Protein	Humans	Unknown	Not Available	Details
Copper	Vitronectin	Protein	Humans	Unknown	Not Available	Details
Copper	Zinc-alpha-2-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-1-acid glycoprotein 2	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-1-antichymotrypsin	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-1-antitrypsin	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-1B-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-2-HS-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Zinc	Alpha-2-macroglobulin	Protein	Humans	Unknown	Not Available	Details
Zinc	Angiotensinogen	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein A-I	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein A-II	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein A-IV	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein B receptor	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein E	Protein	Humans	Unknown	Not Available	Details
Zinc	Apolipoprotein L1	Protein	Humans	Unknown	Not Available	Details
Zinc	Carboxypeptidase N catalytic chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Carboxypeptidase N subunit 2	Protein	Humans	Unknown	Not Available	Details
Zinc	Ceruloplasmin	Protein	Humans	Unknown	Not Available	Details
Zinc	Clusterin	Protein	Humans	Unknown	Not Available	Details
Zinc	Coagulation factor XIII B chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C1q subcomponent subunit B	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C1q subcomponent subunit C	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C1r subcomponent	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C1s subcomponent	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C3	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement C5	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement component C8 alpha chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement component C8 beta chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement component C8 gamma chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement factor B	Protein	Humans	Unknown	Not Available	Details
Zinc	Complement factor I	Protein	Humans	Unknown	Not Available	Details
Zinc	Corticosteroid-binding globulin	Protein	Humans	Unknown	Not Available	Details
Zinc	Desmoplakin	Protein	Humans	Unknown	Not Available	Details
Zinc	Fibronectin	Protein	Humans	Unknown	Not Available	Details
Zinc	Ficolin-3	Protein	Humans	Unknown	Not Available	Details
Zinc	Gelsolin	Protein	Humans	Unknown	Not Available	Details
Zinc	Haptoglobin-related protein	Protein	Humans	Unknown	Not Available	Details
Zinc	Hemoglobin subunit alpha	Protein	Humans	Unknown	Not Available	Details
Zinc	Hornerin	Protein	Humans	Unknown	Not Available	Details
Zinc	Ig alpha-1 chain C region	Protein	Humans	Unknown	Not Available	Details
Zinc	Ig kappa chain V-III region GOL	Protein	Humans	Unknown	Not Available	Details
Zinc	Ig mu chain C region	Protein	Humans	Unknown	Not Available	Details
Zinc	Immunoglobulin J chain	Protein	Humans	Unknown	Not Available	Details
Zinc	Immunoglobulin kappa variable 1-17	Protein	Humans	Unknown	Not Available	Details
Zinc	Immunoglobulin lambda variable 3-21	Protein	Humans	Unknown	Not Available	Details
Zinc	Insulin-like growth factor-binding protein complex acid labile subunit	Protein	Humans	Unknown	Not Available	Details
Zinc	Inter-alpha-trypsin inhibitor heavy chain H1	Protein	Humans	Unknown	Not Available	Details
Zinc	Inter-alpha-trypsin inhibitor heavy chain H2	Protein	Humans	Unknown	Not Available	Details
Zinc	Inter-alpha-trypsin inhibitor heavy chain H3	Protein	Humans	Unknown	Not Available	Details
Zinc	Inter-alpha-trypsin inhibitor heavy chain H4	Protein	Humans	Unknown	Not Available	Details
Zinc	Junction plakoglobin	Protein	Humans	Unknown	Not Available	Details
Zinc	Kallistatin	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type I cytoskeletal 10	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type I cytoskeletal 14	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type I cytoskeletal 16	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type I cytoskeletal 9	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type II cytoskeletal 1	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type II cytoskeletal 2 epidermal	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type II cytoskeletal 5	Protein	Humans	Unknown	Not Available	Details
Zinc	Keratin, type II cytoskeletal 6A	Protein	Humans	Unknown	Not Available	Details
Zinc	N-acetylmuramoyl-L-alanine amidase	Protein	Humans	Unknown	Not Available	Details
Zinc	Plasma kallikrein	Protein	Humans	Unknown	Not Available	Details
Zinc	Pregnancy zone protein	Protein	Humans	Unknown	Not Available	Details
Zinc	Prothrombin	Protein	Humans	Unknown	Not Available	Details
Zinc	Selenoprotein P	Protein	Humans	Unknown	Not Available	Details
Zinc	Serotransferrin	Protein	Humans	Unknown	Not Available	Details
Zinc	Serum amyloid P-component	Protein	Humans	Unknown	Not Available	Details
Zinc	Serum paraoxonase/arylesterase 1	Protein	Humans	Unknown	Not Available	Details
Zinc	Sex hormone-binding globulin	Protein	Humans	Unknown	Not Available	Details
Zinc	Transthyretin	Protein	Humans	Unknown	Not Available	Details
Zinc	Vitronectin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-1-acid glycoprotein 2	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-1-antichymotrypsin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-1-antitrypsin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-1B-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-2-HS-glycoprotein	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Alpha-2-macroglobulin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Angiotensinogen	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein A-I	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein A-II	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein A-IV	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein B receptor	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein E	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Apolipoprotein L1	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Carboxypeptidase N catalytic chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Carboxypeptidase N subunit 2	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Ceruloplasmin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Clusterin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Coagulation factor XIII B chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C1q subcomponent subunit B	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C1q subcomponent subunit C	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C1r subcomponent	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C1s subcomponent	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C3	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement C5	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement component C8 alpha chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement component C8 beta chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement component C8 gamma chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement factor B	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Complement factor I	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Corticosteroid-binding globulin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Desmoplakin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Fibronectin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Ficolin-3	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Gelsolin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Haptoglobin-related protein	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Hemoglobin subunit alpha	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Hornerin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Ig alpha-1 chain C region	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Ig kappa chain V-III region GOL	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Ig mu chain C region	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Immunoglobulin J chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Immunoglobulin kappa variable 1-17	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Immunoglobulin lambda variable 3-21	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Insulin-like growth factor-binding protein complex acid labile subunit	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Inter-alpha-trypsin inhibitor heavy chain H1	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Inter-alpha-trypsin inhibitor heavy chain H2	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Inter-alpha-trypsin inhibitor heavy chain H3	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Inter-alpha-trypsin inhibitor heavy chain H4	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Junction plakoglobin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Kallistatin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type I cytoskeletal 10	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type I cytoskeletal 14	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type I cytoskeletal 16	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type I cytoskeletal 9	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type II cytoskeletal 1	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type II cytoskeletal 2 epidermal	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type II cytoskeletal 5	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Keratin, type II cytoskeletal 6A	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	N-acetylmuramoyl-L-alanine amidase	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Plasma kallikrein	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Pregnancy zone protein	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Prothrombin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Selenoprotein P	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Serotransferrin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Serum amyloid P-component	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Serum paraoxonase/arylesterase 1	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Sex hormone-binding globulin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Transthyretin	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Vitronectin	Protein	Humans	Unknown	Not Available	Details
Zinc chloride	Alpha-1-acid glycoprotein 2	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Alpha-1-antichymotrypsin	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Alpha-1-antitrypsin	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Alpha-2-macroglobulin	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Apolipoprotein A-I	Protein	Humans	Unknown	Inducer Ligand	Details
Zinc chloride	Apolipoprotein B receptor	Protein	Humans	Unknown	Inducer	Details
Zinc chloride	Apolipoprotein B-100	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Ceruloplasmin	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Clusterin	Protein	Humans	Unknown	Inducer	Details
Zinc chloride	Complement C3	Protein	Humans	Unknown	Inhibitor Ligand	Details
Zinc chloride	Complement C5	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Corticosteroid-binding globulin	Protein	Humans	Unknown	Modulator	Details
Zinc chloride	Fibronectin	Protein	Humans	Unknown	Modulator Ligand	Details
Zinc chloride	Hemopexin	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Histidine-rich glycoprotein	Protein	Humans	Unknown	Cofactor	Details
Zinc chloride	Immunoglobulin J chain	Protein	Humans	Unknown	Component of	Details
Zinc chloride	Insulin-like growth factor-binding protein complex acid labile subunit	Protein	Humans	Unknown	Inducer	Details
Zinc chloride	Inter-alpha-trypsin inhibitor heavy chain H1	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Inter-alpha-trypsin inhibitor heavy chain H2	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Inter-alpha-trypsin inhibitor heavy chain H3	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Inter-alpha-trypsin inhibitor heavy chain H4	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Keratin, type I cytoskeletal 9	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	N-acetylmuramoyl-L-alanine amidase	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Plasma kallikrein	Protein	Humans	Unknown	Inhibitor	Details
Zinc chloride	Pregnancy zone protein	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Selenoprotein P	Protein	Humans	Unknown	Binder	Details
Zinc chloride	Serotransferrin	Protein	Humans	Unknown	Ligand	Details
Zinc chloride	Serum paraoxonase/arylesterase 1	Protein	Humans	Unknown	Inducer	Details
Zinc chloride	Sex hormone-binding globulin	Protein	Humans	Unknown	Modulator	Details
Zinc chloride	Transthyretin	Protein	Humans	Unknown	Inducer	Details
Zinc chloride	Vitronectin	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Alpha-1-acid glycoprotein 2	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Alpha-1-antichymotrypsin	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Alpha-1-antitrypsin	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Alpha-2-macroglobulin	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Apolipoprotein A-I	Protein	Humans	Unknown	Inducer Ligand	Details
Zinc sulfate, unspecified form	Apolipoprotein B receptor	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Apolipoprotein B-100	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Ceruloplasmin	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Clusterin	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Complement C3	Protein	Humans	Unknown	Inhibitor Ligand	Details
Zinc sulfate, unspecified form	Complement C5	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Corticosteroid-binding globulin	Protein	Humans	Unknown	Modulator	Details
Zinc sulfate, unspecified form	Fibronectin	Protein	Humans	Unknown	Modulator Ligand	Details
Zinc sulfate, unspecified form	Hemopexin	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Histidine-rich glycoprotein	Protein	Humans	Unknown	Cofactor	Details
Zinc sulfate, unspecified form	Immunoglobulin J chain	Protein	Humans	Unknown	Component of	Details
Zinc sulfate, unspecified form	Insulin-like growth factor-binding protein complex acid labile subunit	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Inter-alpha-trypsin inhibitor heavy chain H1	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Inter-alpha-trypsin inhibitor heavy chain H2	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Inter-alpha-trypsin inhibitor heavy chain H3	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Inter-alpha-trypsin inhibitor heavy chain H4	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Keratin, type I cytoskeletal 9	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	N-acetylmuramoyl-L-alanine amidase	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Plasma kallikrein	Protein	Humans	Unknown	Inhibitor	Details
Zinc sulfate, unspecified form	Pregnancy zone protein	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Selenoprotein P	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Serotransferrin	Protein	Humans	Unknown	Ligand	Details
Zinc sulfate, unspecified form	Serum paraoxonase/arylesterase 1	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Sex hormone-binding globulin	Protein	Humans	Unknown	Modulator	Details
Zinc sulfate, unspecified form	Transthyretin	Protein	Humans	Unknown	Inducer	Details
Zinc sulfate, unspecified form	Vitronectin	Protein	Humans	Unknown	Inducer	Details