Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile.

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Gonzalez AM, Walther D, Pazos A, Uhl GR

Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile.

Brain Res Mol Brain Res. 1994 Mar;22(1-4):219-26.

PubMed ID
7912402 [ View in PubMed
]
Abstract

The human vesicular monoamine transporter (hSVMT) cDNA predicts a protein of 515 amino acids that shares 92% amino acid identity with the rat cDNA. Northern analyses reveal expression of 4.3 kb SVMT mRNAs in rat hypothalamus, midbrain and brainstem, a 3 kb hSVMT mRNA in human brainstem and a 4.8 kb hSVMT mRNA in human hypothalamus. In situ hybridization documents significant SVMT expression in human nigra compacta neurons and in rat hypothalamic neurons whose distribution patterns are identical to those previously reported to display histaminergic markers. COS cell hSVMT expression yielded nanomolar affinities for tetrabenazine and reserpine, micromolar affinities for haloperidol, GBR12909, serotonin, mazindol, nomifensin and d-amphetamine, while dopamine, epinephrine, norepinephrine and histamine each displayed millimolar affinities. These observations extend the pharmacological characterization of hSVMT and studies of its distribution, and indicate likely physiological roles for SVMT in packaging monoamine transmitters including histamine.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DopamineSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails
HaloperidolSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails
HistamineSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails
MazindolSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails
NomifensineSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails
SerotoninSynaptic vesicular amine transporterProteinHumans
Unknown
Not AvailableDetails