Succinate dehydrogenase - Assembly, regulation and role in human disease.

Article Details

Citation

Copy to clipboard

Rutter J, Winge DR, Schiffman JD

Succinate dehydrogenase - Assembly, regulation and role in human disease.

Mitochondrion. 2010 Jun;10(4):393-401. doi: 10.1016/j.mito.2010.03.001. Epub 2010 Mar 10.

PubMed ID

20226277 [ View in PubMed

]

Abstract

Succinate dehydrogenase (or Electron Transport Chain Complex II) has been the subject of a focused but significant renaissance. This complex, which has been the least studied of the mitochondrial respiratory complexes has seen renewed interest due to the discovery of its role in human disease. Under this heightened scrutiny, the succinate dehydrogenase complex has proven to be a fascinating machine, whose regulation and assembly requires additional factors that are beginning to be discovered. Mutations in these factors and in the structural subunits of the complex itself cause a variety of human diseases. The mechanisms underlying the pathogenesis of SDH mutations is beginning to be understood.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Succinic acid	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Protein	Humans	Unknown	Substrate	Details