Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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Ruffolo RR Jr, Bondinell W, Hieble JP

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

J Med Chem. 1995 Sep 15;38(19):3681-716.

PubMed ID
7562902 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
EpinephrineBeta-1 adrenergic receptorEC 50 (nM)15N/AN/ADetails
EpinephrineBeta-1 adrenergic receptorEC 50 (nM)436N/AN/ADetails
NorepinephrineBeta-1 adrenergic receptorEC 50 (nM)10000N/AN/ADetails
NorepinephrineBeta-1 adrenergic receptorEC 50 (nM)30N/AN/ADetails
YohimbineAlpha-2A adrenergic receptorKi (nM)7.5N/AN/ADetails
YohimbineAlpha-2B adrenergic receptorKi (nM)4.6N/AN/ADetails
YohimbineAlpha-2C adrenergic receptorKi (nM)2.3N/AN/ADetails